Chargers vs. Commanders 2025 Prediction, Odds, Picks - Oct 5

The Los Angeles Chargers (3-1) are considered favorites (-2.5) according to the bookmakers ahead of their game against the Washington Commanders (2-2) on October 5, 2025, starting at 4:25 p.m. ET, airing on FOX. The predicted point total for the matchup is 47.5.

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Chargers vs. Commanders Odds & Betting Lines

Chargers vs. Commanders Prediction & Pick

• Pick ATS: Chargers (-2.5)
  
• Pick OU: Under (47.5)
  
• Prediction: Chargers 26 - Commanders 19

How to Watch Los Angeles vs. Washington

• Game date: Sunday, October 5, 2025
• Time: 4:25 p.m. ET
• Venue: SoFi Stadium
• Location: Inglewood, California
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Chargers vs. Commanders Recent Matchups

• Los Angeles has a 2-0 record against Washington in their last two matchups.
• Washington has been outscored by 21 points in its last two tilts against Los Angeles.

Los Angeles Betting Info

• Los Angeles is 3-1-0 against the spread this season.
• The Chargers have covered the spread twice this season (2-1 ATS) when playing as at least 2.5-point favorites.
• Los Angeles games this year have gone over the total in one out of four opportunities (25%).
• When playing as the moneyline favorite, the Chargers are 2-1, picking up a victory 66.7% of the time.
• Looking at this contest's moneyline, the Chargers' implied win probability is 60.8%.

Chargers Stats

Los Angeles' Key Players

Offense

• Justin Herbert ranks fourth in the NFL with 1,063 passing yards through four games this year, averaging 265.8 per game with a 63.8% completion percentage and seven touchdowns (eighth in the NFL) against three interceptions.
• In addition to his passing stats, Herbert also has 93 rushing yards (second on the Chargers), but no touchdowns.
• Quentin Johnston has 22 receptions for 337 yards (fifth in the NFL) and four TDs. In four games, he is averaging 5.5 catches and 84.3 yards per game.
• Omarion Hampton's output on the ground this season includes 270 yards and two TDs. He is averaging 67.5 yards per game and 5 per attempt (12th in the NFL).
• Hampton also has 14 receptions, 110 yards and zero TDs through the air.
• Keenan Allen has 231 receiving yards and three touchdowns (eighth in the NFL) with 24 catches (ninth in the NFL) on 35 targets. He is averaging six receptions and 57.8 yards per game.

Defense

• On the defensive side, Tuli Tuipulotu has 17 tackles, six TFL, and four sacks in 2025.
• Derwin James has 34 tackles, five TFL, and 1.5 sacks this season.
• Daiyan Henley has recorded one interception and added 31 tackles, three TFL, two sacks, and two passes defended.
• So far this season, Tarheeb Still has 18 tackles and one TFL.

Washington Betting Info

• Washington has covered the spread two times this season (2-2-0).
• The Commanders have yet to cover the spread this year when underdogs by 2.5 points or more.
• Washington games have gone over the total twice this year.
• The Commanders have lost both games they've played as underdogs this season.
• The implied probability of a win by the Commanders based on the moneyline is 43.5%.

Commanders Stats

Washington's Key Players

Offense

• Deebo Samuel has put up 204 receiving yards and two touchdowns on 22 receptions, while being targeted 27 times this season.
• In two games, Jayden Daniels has 433 passing yards, while throwing three touchdowns against zero interceptions and completing 59.7% of his attempts.
• He has tacked on 85 rushing yards (fourth on the Commanders), with zero touchdowns on the ground (averaging 42.5 yards per game and 4.7 per carry).
• Marcus Mariota has thrown for 363 yards this year, three touchdowns and one interception. He is completing 64.6% of his attempts while averaging 181.5 yards per game and 7.6 per attempt.
• He's added 60 yards on the ground (fifth on the Commanders), while scoring one rushing touchdown. He's averaging 30 yards per game and 7.5 per attempt.
• Jacory Croskey-Merritt has scored two touchdowns on the ground, while running for 172 total yards (5.9 per carry and 43 per game).

Defense

• So far in 2025, Bobby Wagner has amassed 42 tackles, four TFL, and two sacks over four games.
• Dorance Armstrong Jr. has 19 tackles, five TFL, and three sacks. He is third on the Commanders in tackles.
• Da'Ron Payne has 15 tackles, three TFL, and one sack in the 2025 season.
• Frankie Luvu's season stats include 24 tackles, one TFL, and one sack through four games. He is second on the Commanders in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Los Angeles Chargers

Washington Commanders