49ers vs. Titans 2025 Prediction, Odds, Picks - Dec 14

The San Francisco 49ers (9-4) will be trying to extend a three-game winning run against the Tennessee Titans (2-11). The 49ers are heavy favorites (-12.5). The over/under for this one is set at 44.5 points.

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49ers vs. Titans Odds & Betting Lines

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49ers vs. Titans Prediction & Pick

• Pick ATS: 49ers (-12.5)
  
• Pick OU: Under (44.5)
  
• Prediction: 49ers 32 - Titans 12

How to Watch San Francisco vs. Tennessee

• Game date: Sunday, December 14, 2025
• Time: 4:25 p.m. ET
• Venue: Levi's Stadium
• Location: Santa Clara, California
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

49ers vs. Titans Recent Matchups

• The last two times Tennessee and San Francisco have squared off, the two teams share a split 1-1 record.
• Over their last two head-to-head contests, Tennessee has racked up 43 points, while San Francisco has accumulated 42.

San Francisco Betting Info

• San Francisco has eight wins in 13 games versus the spread this year.
• San Francisco has combined with its opponent to hit the over in 53.8% of its contests this year (seven times in 13 games with a set point total).
• When playing as moneyline favorites, the 49ers are 8-1, earning a win 88.9% of the time.
• The 49ers have a 90.0% chance to win this game, based on the implied probability of the moneyline.

49ers Stats

San Francisco's Key Players

Offense

• Christian McCaffrey has collected 849 rushing yards with eight touchdowns (65.3 yards per game over 13 games). His 3.6 yards per attempt rank 40th in the league.
• McCaffrey has been targeted 107 times in the receiving game and has 85 catches (6.5 per game) for 806 yards (62.0 per game) and five TDs.
• Mac Jones has thrown for 2,151 yards, 13 touchdowns and six interceptions this year. He averages 215.1 yards per game and 7.4 per attempt, while completing 69.6%.
• Brock Purdy has 1,147 passing yards through five games this year, averaging 229.4 per game with a 66.3% completion percentage and nine touchdowns against seven interceptions.
• He has also rushed for 43 yards (fourth on the 49ers) and added one touchdown on the ground, averaging 8.6 yards per game.
• Jauan Jennings averages 3.7 receptions and 41.6 yards per game, and has 458 total receiving yards and 41 catches. He's gotten 69 total targets, and has caught five touchdown passes.

Defense

• On the defensive side, Dee Winters has 84 tackles and 6.0 TFL in 2025. His tackle total leads the 49ers.
• Upton Stout has 64 tackles, 4.0 TFL, and one sack this season.
• Bryce Huff has collected 23 tackles, 6.0 TFL, and four sacks this year.
• This season, Ji'Ayir Brown has 44 tackles, 1.0 TFL, and two interceptions.

Tennessee Betting Info

• Tennessee has covered the spread in a matchup six times this year (6-7-0).
• The Titans have yet to cover the spread this year when underdogs by 12.5 points or more.
• This season, eight Tennessee games have gone over the point total.
• This season, the Titans have been the underdog 13 times and won two of those games.
• The Titans have a 14.3% chance to win this game based on the implied probability of the moneyline.

Titans Stats

Tennessee's Key Players

Offense

• Cameron Ward is averaging 5.6 passing yards per attempt (33rd in the NFL) and 189.8 yards per game this year, completing 59.1% of his passes on the way to 2,468 total yards, nine touchdowns and seven interceptions through 13 games.
• On the ground, Ward has added one rushing touchdown and 127 rushing yards (third on the Titans).
• Tony Pollard averages 57.2 rushing yards per game through 13 games (743 total yards), while scoring four rushing touchdowns.
• Pollard has added 27 receptions (2.1 per game) for 171 yards (13.2 per game), without a receiving touchdown. He's been targeted 34 times in the passing game.
• So far this season, Chimere Dike has caught 34 passes for 284 receiving yards with three touchdowns in the passing game. He has been targeted 55 total times and is averaging 2.6 receptions per game in 13 games played.
• Elic Ayomanor has 30 catches for 353 yards and three receiving touchdowns. He averages 2.5 yards per game through 12 games and has been targeted 67 times.

Defense

• So far in 2025, Cedric Gray has amassed 124 tackles, 6.0 TFL, and one sack through 13 games.
• Jeffery Simmons' stat sheet includes 48 tackles, 12.0 TFL, eight sacks, and one pass defended.
• In the 2025 campaign, Cody Barton has 67 tackles, 4.0 TFL, one sack, and three interceptions through 13 games.
• Amani Hooker's season stats include 69 tackles, 3.0 TFL, and one sack in 13 games. He is second on the Titans in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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