49ers vs. Titans 2025 Prediction, Odds, Picks - Dec 14

The San Francisco 49ers (9-4) are heavy favorites (-12.5) over the Tennessee Titans (2-11). The 49ers have taken three games in a row. An over/under of 44.5 points has been set for the matchup.

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49ers vs. Titans Odds & Betting Lines

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49ers vs. Titans Prediction & Pick

• Pick ATS: 49ers (-12.5)
  
• Pick OU: Under (44.5)
  
• Prediction: 49ers 32 - Titans 12

How to Watch San Francisco vs. Tennessee

• Game date: Sunday, December 14, 2025
• Time: 4:25 p.m. ET
• Venue: Levi's Stadium
• Location: Santa Clara, California
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

49ers vs. Titans Recent Matchups

• San Francisco and Tennessee have been matched up evenly over their last two games, sharing the same 1-1 record.
• In their last two head-to-head matchups, Tennessee has racked up 43 points against San Francisco, while allowing only 42 points.

San Francisco Betting Info

• San Francisco has played 13 games, posting eight wins against the spread.
• San Francisco contests this year have eclipsed the over/under 53.8% of the time (seven times in 13 games with a set point total).
• The 49ers have compiled an 8-1 record in games they played as moneyline favorite (winning 88.9% of those games).
• The 49ers have a 90.0% chance to win this game, based on the implied probability of the moneyline.

49ers Stats

San Francisco's Key Players

Offense

• On the ground, Christian McCaffrey averages 3.6 yards per attempt (40th in the NFL) and 65.3 yards per game for 849 total rushing yards. He has recorded eight rushing touchdowns this season.
• McCaffrey has been targeted 107 times in the passing game and has 85 catches (6.5 per game) for 806 yards (62.0 per game) and five TDs.
• Mac Jones has thrown for 2,151 yards, 13 touchdowns and six interceptions this year. He averages 215.1 yards per game and 7.4 per attempt, while completing 69.6%.
• Brock Purdy has 1,147 passing yards, nine touchdowns and seven interceptions this year. He has completed 66.3% of his attempts, averaging 229.4 yards per game and 7.2 per attempt.
• He has added 43 rushing yards (8.6 per game) and one touchdown on the ground.
• Jauan Jennings averages 3.7 receptions and 41.6 yards per game, and has 458 total receiving yards and 41 catches. He's gotten 69 total targets, and has caught five touchdown passes.

Defense

• Over on the defensive side, Dee Winters has 84 tackles and 6.0 TFL in 2025. His tackle total leads the 49ers.
• Upton Stout has 64 tackles, 4.0 TFL, and one sack this season.
• This season, Bryce Huff has put up 4.0 sacks (first on the 49ers) as well as 6.0 TFL and 23 tackles.
• Ji'Ayir Brown has 1.0 TFL, 44 tackles, and two interceptions this year.

Tennessee Betting Info

• Tennessee has gone 6-7-0 against the spread this season.
• The Titans have yet to cover the spread this season when underdogs by 12.5 points or more.
• This season, eight Tennessee games have gone over the point total.
• The Titans have won two, or 15.4%, of the 13 games they've played as underdogs this season.
• The moneyline for this contest implies a 14.3% chance of a victory for the Titans.

Titans Stats

Tennessee's Key Players

Offense

• Cameron Ward has thrown for 2,468 yards this year, with nine touchdowns and seven interceptions. He is completing 59.1% of his passes while averaging 189.8 yards per game and 5.6 per attempt.
• He's added 127 yards on the ground (third on the Titans), with one rushing touchdown. He's averaging 9.8 yards per game and 4.2 per attempt.
• Tony Pollard has 743 rushing yards (leading the Titans) and four rushing touchdowns, while averaging 57.2 yards per game and 4.2 per carry (23rd in the NFL).
• Pollard also has 27 catches for 171 yards (eighth on the Titans). He has been targeted 34 times and averages 13.2 yards per game.
• Chimere Dike has recorded 284 receiving yards and three touchdowns on 34 receptions, while being targeted 55 times this season.
• Elic Ayomanor has been targeted 67 times, resulting in 30 catches for 353 yards .

Defense

• Cedric Gray has 124 tackles, 6.0 TFL, one sack, and four passes defended in 2025.
• Jeffery Simmons has 8.0 sacks (first on the Titans) to go with 12.0 TFL and 48 tackles.
• Cody Barton has 1.0 sack as well as 4.0 TFL, 67 tackles, and three interceptions in the 2025 campaign.
• Amani Hooker has 69 tackles, 3.0 TFL, one sack, and seven passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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San Francisco 49ers

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