49ers vs. Bears 2025 Prediction, Odds, Picks - Dec 28

Having won five straight, the San Francisco 49ers (11-4) will face the Chicago Bears (11-4). The 49ers are the favorites, expected to win by at least a field goal but less than a touchdown (currently -3.5). The matchup has an over/under of 51.5 points.

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49ers vs. Bears Odds & Betting Lines

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49ers vs. Bears Prediction & Pick

• Pick ATS: 49ers (-3.5)
  
• Pick OU: Under (51.5)
  
• Prediction: 49ers 30 - Bears 19

How to Watch San Francisco vs. Chicago

• Game date: Sunday, December 28, 2025
• Time: 8:20 p.m. ET
• Venue: Levi's Stadium
• Location: Santa Clara, California
• TV: NBC/Peacock
• Live Boxscore: FOX Sports

49ers vs. Bears Recent Matchups

• Over their last five meetings, San Francisco has tallied three wins versus Chicago.
• Chicago has been outscored by 23 points in its last five tilts versus San Francisco.

San Francisco Betting Info

• Against the spread, San Francisco is 10-5-0 this season.
• The 49ers have won each of their four games this season when playing as at least 3.5-point favorites.
• San Francisco has combined with its opponent to gone over the point total in 60% of its contests this year (nine times over 15 games with a set point total).
• When playing as the moneyline favorite, the 49ers have won 90.9% of the time (10-1).
• Looking at this matchup's moneyline, the 49ers' implied win probability is 64.9%.

49ers Stats

San Francisco's Key Players

Offense

• Christian McCaffrey's rushing output this season includes 1,039 yards and nine TDs. He is averaging 69.3 yards per game and 3.7 per attempt (44th in the NFL).
• McCaffrey has 116 targets, 92 receptions, 849 receiving yards and seven TDs in the passing game.
• Brock Purdy has 1,737 passing yards, 17 touchdowns and eight interceptions this year. He has completed 68.8% of his attempts, averaging 248.1 yards per game and 7.8 per attempt.
• He has added 98 rushing yards (14.0 per game) and one touchdown on the ground.
• Mac Jones has 2,151 passing yards in 11 games this year, averaging 195.5 per game with a 69.6% completion percentage and 13 touchdowns against six interceptions.
• Jauan Jennings averages 3.8 receptions and 43.5 yards per game, and has 566 total receiving yards and 49 catches. He's gotten 80 total targets, and has caught eight touchdown passes (ninth in the NFL).

Defense

• On defense, Dee Winters has 7.0 TFL, 92 tackles, and one interception in 2025.
• Upton Stout has 72 tackles, 4.0 TFL, and one sack this season.
• Ji'Ayir Brown has recorded 51 tackles, 2.0 TFL, and two interceptions this year.
• Malik Mustapha has 3.0 TFL, 68 tackles, and one interception on the year.

Chicago Betting Info

• Chicago has covered the spread in a game 10 times this year (10-5-0).
• The Bears have covered the spread twice this year when underdogs by 3.5 points or more (in four chances).
• This year, seven Chicago games have gone over the point total.
• This season, the Bears have won five out of the nine games in which they've been the underdog.
• The moneyline for this contest implies a 39.4% chance of a victory for the Bears.

Bears Stats

Chicago's Key Players

Offense

• Caleb Williams has thrown for 3,400 yards this year, with 23 touchdowns and six interceptions. He is completing 57.8% of his attempts while averaging 226.7 yards per game and 6.9 per attempt.
• He's added 369 yards on the ground (third on the Bears), while scoring three rushing touchdowns. He's averaging 24.6 yards per game and 5.2 per attempt.
• D'Andre Swift has 993 rushing yards (leading the Bears) and seven rushing touchdowns, while averaging 70.9 yards per game and 4.9 per carry (11th in the NFL).
• Swift has added 31 receptions (2.2 per game) for 266 yards (19.0 per game) with one receiving touchdown. He's been targeted 43 times in the passing game.
• Kyle Monangai is averaging 48.7 rushing yards per game this season (731 total yards), while scoring five rushing touchdowns.
• D.J. Moore has 664 receiving yards and six touchdowns from 48 receptions after receiving 78 targets.

Defense

• So far in 2025, Montez Sweat has put up 44 tackles, 13.0 TFL, and 9.5 sacks through 15 games.
• Tremaine Edmunds has registered 1.0 sack in addition to his 3.0 TFL, 95 tackles, and four interceptions over 11 games.
• Nahshon Wright has 3.0 TFL, 67 tackles, and five interceptions in the 2025 campaign.
• Kevin Byard has intercepted six passes in addition to 83 tackles, 4.0 TFL, and seven passes defended. He's first in the NFL in interceptions.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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San Francisco 49ers

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