49ers vs. Bears 2025 Prediction, Odds, Picks - Dec 28

Published Dec. 26, 2025 8:43 p.m. ET

Data Skrive

The San Francisco 49ers (11-4) will be attempting to continue a five-game winning streak against the Chicago Bears (11-4). The 49ers are the favorites, expected to win by at least a field goal but less than a touchdown (currently -3). The total for this one is set at 52.5 points.

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49ers vs. Bears Odds & Betting Lines

49ers vs Bears Betting Information updated as of December 26, 2025, 5:33 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
49ers	-3	-112	-108	52.5	-110	-110

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49ers vs. Bears Prediction & Pick

Pick ATS: 49ers (-3)
Pick OU: Under (52.5)
Prediction: 49ers 30 - Bears 19

How to Watch San Francisco vs. Chicago

Game date: Sunday, December 28, 2025
Time: 8:20 p.m. ET
Venue: Levi's Stadium
Location: Santa Clara, California
TV: NBC/Peacock
Live Boxscore: FOX Sports

49ers vs. Bears Recent Matchups

Over their last five meetings, San Francisco has tallied three wins versus Chicago.
Chicago has been outpaced by 23 points in its last five tilts versus San Francisco.

San Francisco Betting Info

Against the spread, San Francisco is 10-5-0 this year.
The 49ers have been favored by 3 points or more seven times this season, and covered the spread in six of those matchups.
San Francisco contests this year have gone over the point total 60% of the time (nine times in 15 games with a set point total).
When playing as moneyline favorites, the 49ers are 10-1 (winning 90.9% of the time).
The implied probability for this matchup, considering the moneyline, gives the 49ers a 62.4% chance to win.

49ers Stats

Stat	Average (Total)	Rank
Pass yards	249.4 (3,741)	5
Rush yards	104.3 (1,564)	25
Points scored	26.1 (392)	9
Pass yards against	229.3 (3,440)	24
Rush yards against	102.9 (1,543)	8
Points allowed	21.3 (320)	12

San Francisco's Key Players

Offense

Christian McCaffrey's rushing stat line this season includes 1,039 yards (10th in the NFL) and nine TDs. He's averaging 69.3 yards per game and 3.7 per attempt (43rd in the NFL).
McCaffrey has been targeted 116 times in the receiving game and has 92 catches (6.1 per game) for 849 yards (56.6 per game) and seven TDs.
Brock Purdy has thrown for 1,737 yards, 17 touchdowns and eight interceptions this year. He averages 248.1 yards per game and 7.8 per attempt, while completing 68.8%.
He has added 98 rushing yards (14.0 per game) and one touchdown on the ground.
Mac Jones has 2,151 passing yards through 11 games this year, averaging 195.5 per game with a 69.6% completion percentage and 13 touchdowns against six interceptions.
Jauan Jennings averages 3.8 receptions and 43.5 yards per game, and has 566 total receiving yards and 49 catches. He's gotten 80 total targets, and has caught eight touchdown passes (eighth in the NFL).

Defense

On the defensive side, Dee Winters has 7.0 TFL, 92 tackles, and one interception in 2025.
Upton Stout has 72 tackles, 4.0 TFL, and one sack this season.
Ji'Ayir Brown has collected two interceptions and added 51 tackles, 2.0 TFL, and five passes defended.
Malik Mustapha has one interception while tacking on 68 tackles, 3.0 TFL, and two passes defended.

Chicago Betting Info

Chicago has gone 10-5-0 against the spread this year.
This year, the Bears have two ATS wins in four games as an underdog of 3 points or more.
Chicago's games have finished with a final combined score above the over/under seven times this year.
The Bears have entered the game as underdogs nine times this season and won five of those games.
The bookmakers' moneyline implies a 41.7% chance of a victory for the Bears.

Bears Stats

Stat	Average (Total)	Rank
Pass yards	219.4 (3,291)	14
Rush yards	152.1 (2,281)	2
Points scored	25.8 (387)	10
Pass yards against	217.1 (3,256)	18
Rush yards against	131.0 (1,965)	27
Points allowed	23.6 (354)	19

Chicago's Key Players

Offense

Through 15 games played this year, Caleb Williams has totaled 3,400 passing yards, with 23 touchdowns against six interceptions and completing 57.8% of his passes.
Williams has also rushed for three touchdowns and 369 yards (third on the Bears).
D'Andre Swift averages 70.9 rushing yards per game through 14 games (993 total yards), while scoring seven rushing touchdowns.
Swift also has 31 catches for 266 yards (seventh on the Bears), with one receiving touchdown. He has been targeted 43 times and averages 19.0 yards per game.
Kyle Monangai is averaging 48.7 rushing yards per game this season (731 total yards), while scoring five rushing touchdowns.
D.J. Moore has 48 catches for 664 yards and six receiving touchdowns. He averages 3.2 yards per game in 15 games and has been targeted 78 times.

Defense

Montez Sweat has 44 tackles, 13.0 TFL, 9.5 sacks, and five passes defended in 2025.
Tremaine Edmunds has registered 1.0 sack in addition to his 3.0 TFL, 95 tackles, and four interceptions through 11 games.
Nahshon Wright has 67 tackles, 3.0 TFL, and five interceptions in the 2025 season. He is fourth on the Bears in tackles.
Kevin Byard's season stats include 83 tackles, 4.0 TFL, and six interceptions in 15 games. He is second on the Bears in tackles.