Yankees vs. Orioles Prediction, Odds, Picks - September 21

Aaron Judge and the New York Yankees will look to get to Kyle Bradish when he takes the mound for the Baltimore Orioles on Sunday at 1:35 p.m. ET. Bookmakers list the Yankees as -135 favorites on the moneyline, while giving the underdog Orioles +114 moneyline odds. New York is the favorite on the run line (-1.5). The over/under is 8.5 runs for the contest.

Take a look at everything you need to know from a betting perspective on the Yankees-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Yankees vs. Orioles Highlights | MLB on FOX

Check out the best moments between the New York Yankees and Baltimore Orioles.

Yankees vs. Orioles Game Information & Odds

• When: Sunday, September 21, 2025 at 1:35 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: MASN and YES

Yankees vs. Orioles Prediction

• Score Prediction: Yankees 4, Orioles 3
• Total Prediction: Under 8.5 runs
• Win Probabilities: Yankees 53%, Orioles 47%

Yankees vs. Orioles Betting Insights

• The Yankees have been favorites in 132 games this season and won 77 (58.3%) of those contests.
• New York has a record of 65-41, a 61.3% win rate, when favored by -135 or more by bookmakers this season.
• The moneyline for this contest implies a 57.4% chance of a victory for the Yankees.
• The Orioles have won in 40, or 45.5%, of the 88 contests they have been named as odds-on underdogs this year.
• This year, Baltimore has won 20 of 50 games when listed as at least +114 or worse on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Orioles have a 46.7% chance of pulling out a win.

Yankees Recent Betting Performance

• The Yankees have a 7-2 record over the nine games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Yankees and their opponents combined to hit the over four times.
• The Yankees have gone 6-4-0 against the spread over their past 10 games.

Yankees Recent Stats

Yankees Player Insights

• Judge paces the Yankees with 49 home runs and 105 runs batted in, while racking up a team-best batting average of .329.
• In all of Major League Baseball, Judge ranks fourth in homers and eighth in RBI.
• Judge brings a hitting streak of two games into this game. In his last five games he is hitting .438 with a double, a home run, five walks and three RBIs.
• Cody Bellinger is hitting .272 with 25 doubles, five triples, 29 home runs and 51 walks.
• Bellinger ranks 28th in homers in the majors, and 14th in RBI.
• Trent Grisham is batting .240 with nine doubles, a triple, 33 home runs and 74 walks.
• Jazz Chisholm has 14 doubles, a triple, 30 home runs and 56 walks while hitting .242.
• Chisholm is riding a three-game hitting streak into this one. In his last five games he is hitting .250 with a double, a home run and three RBIs.

Yankees Team Props

Orioles Recent Betting Performance

• The Orioles have played as underdogs in seven of their past 10 games and have gone 2-5 in those contests.
• When it comes to hitting the over, the Orioles and their opponents are 3-7-0 in their last 10 games with a total.
• The Orioles have won four of their last 10 games against the spread.

Orioles Recent Stats

Orioles Player Insights

• The Orioles are led in runs batted in by Gunnar Henderson with a mark of 65, he also leads the team in hitting, posting an average of .275.
• Among all hitters in the majors, Henderson is 121st in home runs and 95th in RBI.
• Henderson carries a five-game hitting streak into this matchup. During his last five outings he is batting .429 with a double, a walk and three RBIs.
• Jackson Holliday has racked up a team-high 17 home runs.
• Holliday ranks 108th overall in homers and 137th in RBI this season.
• Jordan Westburg has nine doubles, a triple, 15 home runs and 17 walks while hitting .261.
• Ryan Mountcastle is hitting .256 with 18 doubles, six home runs and 14 walks.

Orioles Team Props

Yankees vs. Orioles Highlights | MLB on FOX

Check out the best moments between the New York Yankees and Baltimore Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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