Twins vs. White Sox Prediction, Odds, Picks - August 22

Trevor Larnach and the Minnesota Twins will play Miguel Vargas and the Chicago White Sox on Friday at Rate Field, at 7:40 p.m. ET. Oddsmakers list the Twins as -130 moneyline favorites, while giving the underdog White Sox +109 moneyline odds. Minnesota is favored on the run line (-1.5 with +131 odds). An 8.5-run total has been listed for this matchup.

Here's everything you need to know from a betting perspective on the Twins-White Sox game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Athletics vs. Twins Highlights | MLB on FOX

Check out the best highlights between the Athletics and the Minnesota Twins.

Twins vs. White Sox Game Information & Odds

• When: Friday, August 22, 2025 at 7:40 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and MNNT

Twins vs. White Sox Prediction

• Score Prediction: White Sox 5, Twins 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Twins 52%, White Sox 48%

Twins vs. White Sox Betting Insights

• The Twins have been favorites in 73 games this season and won 36 (49.3%) of those contests.
• Minnesota has a record of 23-19, a 54.8% win rate, when favored by -130 or more by bookmakers this season.
• Oddsmakers have implied with the moneyline set for this matchup that the Twins have a 56.5% chance to win.
• The White Sox have won in 44, or 35.2%, of the 125 contests they have been named as odds-on underdogs this year.
• Chicago has a win-loss record of 43-75 when favored by +109 or worse by bookmakers this year.
• The White Sox have an implied victory probability of 47.8% according to the moneyline set for this matchup.

Twins Recent Betting Performance

• The Twins did not win a game while favored on the moneyline in the last 10 games in three tries.
• Over their last 10 matchups, the Twins and their opponents combined to go over the run total four times (all 10 of the games had set totals).
• The Twins have put together a 3-7-0 record against the spread over their past 10 games.

Twins Recent Stats

Twins Player Insights

• Not only does Byron Buxton lead the Twins in hitting with his .270 average, he also paces the squad with 25 home runs and 61 RBI.
• In all of MLB, Buxton ranks 22nd in home runs and 65th in RBI.
• Larnach is batting .247 with 18 doubles, a triple, 16 home runs and 41 walks.
• Larnach ranks 85th in homers and 118th in RBI among all major league hitters this season.
• Larnach heads into this game looking for his fifth game in a row with a hit. In his last five games he is batting .263 with two doubles, two walks and an RBI.
• Brooks Lee is batting .249 with 13 doubles, a triple, 13 home runs and 22 walks.
• Ryan Jeffers is batting .262 with 22 doubles, nine home runs and 41 walks.

Twins Team Props

White Sox Recent Betting Performance

• In 10 games over the last 10 matchups when set as underdogs by oddsmakers, the White Sox had a record of 3-7.
• In their last 10 games with a total, the White Sox and their opponents are 4-6-0 when it comes to hitting the over.
• The White Sox are 7-3-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Vargas is hitting .231 with 27 doubles, two triples, 13 home runs and 43 walks, while getting on base at a rate of .307.
• Among all hitters in the majors, Vargas ranks 118th in home runs and 139th in RBI.
• Andrew Benintendi has 14 doubles, two triples, 14 home runs and 32 walks while batting .227.
• Benintendi ranks 112th among all hitters in the majors in home runs, and 134th in RBI.
• Lenyn Sosa has racked up a club-best .271 batting average, and leads the White Sox in home runs (17) and runs batted in (55).
• Luis Robert has 12 doubles, 13 home runs and 40 walks while batting .220.

White Sox Team Props

Guardians vs. White Sox Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Chicago White Sox..

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Chicago White Sox

Minnesota Twins