Tigers vs. Guardians Prediction, Odds, Picks - September 17

Kerry Carpenter and the Detroit Tigers will see Gavin Williams starting for the Cleveland Guardians in the second game of a three-game series, Wednesday at 6:40 p.m. ET. Oddsmakers list the Tigers as -144 favorites on the moneyline, while giving the underdog Guardians +121 moneyline odds to win. Detroit is the run-line favorite (-1.5). The game's over/under is listed at 8 runs.

Take a look at everything you need from a betting perspective on the Tigers-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Tigers vs. Guardians Game Information & Odds

• When: Wednesday, September 17, 2025 at 6:40 p.m. ET
• Where: Comerica Park in Detroit, Michigan
• How to watch on TV: Fox Sports 1, FDSDET, and CLEG

Tigers vs. Guardians Prediction

• Score Prediction: Tigers 5, Guardians 4
• Total Prediction: Over 8 runs
• Win Probabilities: Tigers 54%, Guardians 46%

Tigers vs. Guardians Betting Insights

• The Tigers have won 63, or 60%, of the 105 games they've played as favorites this season.
• Detroit has entered 63 games this season favored by -144 or more and is 43-20 in those contests.
• The moneyline for this contest implies a 59% chance of a victory for the Tigers.
• The Guardians have been underdogs in 83 games this season and have come away with the win 38 times (45.8%) in those contests.
• This season, Cleveland has been victorious 20 times in 37 chances when named as an underdog of at least +121 or worse on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Guardians have a 45.2% chance of pulling out a win.

Tigers Recent Betting Performance

• The Tigers have a 2-5 record from the seven games they were moneyline favorites over their last 10 matchups.
• In their last 10 outings (all had set totals), the Tigers combined with their opponents to hit the over on the run total eight times.
• The Tigers have a 4-6-0 record against the spread over their past 10 games.

Tigers Recent Stats

Tigers Player Insights

• Gleyber Torres has 21 doubles, 16 home runs and 82 walks while batting .254.
• Torres is 117th in homers and 64th in RBI among all hitters in MLB.
• Riley Greene has shown off his power as he paces his team with 34 home runs and 108 RBI, with a team-high .265 batting average.
• Among all major league batters, Greene is 10th in homers and fifth in RBI.
• Spencer Torkelson is batting .242 with 26 doubles, a triple, 29 home runs and 68 walks.
• Torkelson has at least one base hit in three straight games. During his last five outings he is hitting .368 with a home run, three walks and two RBIs.
• Zach McKinstry has 21 doubles, 11 triples, 11 home runs and 45 walks while hitting .261.

Tigers Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs three times over their past 10 games and won each of those contests.
• In their last 10 games with a total, the Guardians and their opponents have combined to hit the over two times.
• The Guardians have a record of 8-2-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez paces the Guardians with 28 home runs and 78 runs batted in, while posting a team-best batting average of .282.
• Ramirez's home run total places him 29th in the big leagues, and he ranks 47th in RBI.
• Steven Kwan is batting .274 with 27 doubles, a triple, 10 home runs and 52 walks.
• Kwan ranks 202nd in home runs and 169th in RBI among all hitters in the big leagues.
• Kyle Manzardo is hitting .241 with 16 doubles, two triples, 26 home runs and 46 walks.
• Angel Martinez is batting .228 with 22 doubles, two triples, 11 home runs and 19 walks.

Guardians Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Detroit Tigers

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