Reds vs. Cubs Prediction, Odds, Picks - September 20

Zack Littell takes the mound for the Cincinnati Reds on Saturday at Great American Ball Park against Nico Hoerner and the Chicago Cubs. First pitch is at 6:40 p.m. ET for the third game of a four-game series. Bookmakers list the Reds as -113 favorites on the moneyline, while giving the underdog Cubs -106 moneyline odds. Chicago is favored on the run line (-1.5). The total is 9 runs for this game.

Here is everything you need from a betting perspective on the Reds-Cubs game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Reds Highlights | MLB on FOX

Check out the best highlights between the Chicago Cubs vs. Cincinnati Reds.

Reds vs. Cubs Game Information & Odds

• When: Saturday, September 20, 2025 at 6:40 p.m. ET
• Where: Great American Ball Park in Cincinnati, Ohio
• How to watch on TV: FDSOH and MARQ

Reds vs. Cubs Prediction

• Score Prediction: Reds 5, Cubs 4
• Total Prediction: Under 9 runs
• Win Probabilities: Reds 50%, Cubs 50%

Reds vs. Cubs Betting Insights

• The Reds have been favorites in 67 games this season and won 35 (52.2%) of those contests.
• Cincinnati has a record of 33-30, a 52.4% win rate, when favored by -113 or more by sportsbooks this season.
• Bookmakers have implied with the moneyline set for this matchup that the Reds have a 53.1% chance to win.
• The Cubs have come away with 18 wins in the 43 contests they have been listed as the underdogs in this season.
• This season, Chicago has come away with a win 17 times in 38 chances when named as an underdog of at least -106 or longer on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Cubs have a 51.5% chance of pulling out a win.

Reds Recent Betting Performance

• The Reds were favored on the moneyline in five of their last 10 games, and they went 2-3 in those matchups.
• Over their last 10 matchups, the Reds and their opponents combined to hit the over four times (all 10 of the games had set totals).
• The Reds have put together a 5-5-0 record against the spread over their past 10 games.

Reds Recent Stats

Reds Player Insights

• Elly De La Cruz leads the Reds in home runs (20) and runs batted in (83).
• Including all MLB batters, De La Cruz is 58th in batting average, 62nd in on-base percentage, and 71st in slugging.
• TJ Friedl is batting .257 with 20 doubles, two triples, 12 home runs and 76 walks.
• Friedl ranks 165th in homers and 172nd in RBI among all hitters in MLB.
• Spencer Steer paces the Reds with 20 home runs.
• Austin Hays is batting .269 with 16 doubles, five triples, 15 home runs and 29 walks.
• Hays is riding a four-game hitting streak into this one. During his last five outings he is hitting .333 with a double and a walk.

Reds Team Props

Cubs Recent Betting Performance

• The Cubs have played as underdogs in four of their past 10 games and won two of those contests.
• When it comes to hitting the over, the Cubs and their opponents are 4-5-1 in their last 10 games with a total.
• The Cubs have a record of 8-2-0 ATS over their last 10 games.

Cubs Recent Stats

Cubs Player Insights

• Hoerner paces the Cubs with a .300 batting average.
• Among all hitters in MLB, Hoerner's home run total ranks 273rd and his RBI tally ranks 119th.
• Pete Crow-Armstrong has shown off his power as he leads his team with 29 home runs.
• Crow-Armstrong is 27th in homers and 24th in RBI among all MLB hitters this year.
• Ian Happ is batting .243 with 29 doubles, 23 home runs and 85 walks.
• Seiya Suzuki has a team-leading 91 runs batted in.

Cubs Team Props

Cubs vs. Reds Highlights | MLB on FOX

Check out the best highlights between the Chicago Cubs vs. Cincinnati Reds.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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