Reds vs. Cardinals Prediction, Odds, Picks - September 16

Andrew Abbott and Michael McGreevy are the projected starters when the Cincinnati Reds and the St. Louis Cardinals square off on Tuesday at Busch Stadium, at 7:45 p.m. ET. The favored Reds have -123 moneyline odds against the underdog Cardinals, who are listed at +103. Cincinnati is a 1.5-run favorite (at +137 odds). The total for the contest is set at 8 runs.

Here's everything you need from a betting perspective on the Reds-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Reds vs. Cardinals Game Information & Odds

• When: Tuesday, September 16, 2025 at 7:45 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: FDSMW and FDSOH

Reds vs. Cardinals Prediction

• Score Prediction: Cardinals 6, Reds 5
• Total Prediction: Over 8 runs
• Win Probabilities: Reds 51%, Cardinals 49%

Reds vs. Cardinals Betting Insights

• The Reds have been favorites in 64 games this season and won 33 (51.6%) of those contests.
• Cincinnati has a record of 25-20, a 55.6% win rate, when favored by -123 or more by bookmakers this season.
• The sportsbooks' moneyline implies a 55.2% chance of a victory for the Reds.
• The Cardinals have been victorious in 39, or 47%, of the 83 contests they have been chosen as underdogs in this season.
• St. Louis has a mark of 24-37 in contests where oddsmakers favor it by +103 or worse on the moneyline.
• The Cardinals have an implied victory probability of 49.3% according to the moneyline set by sportsbooks for this matchup.

Reds Recent Betting Performance

• The Reds have a 1-2 record over the three games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 matchups, the Reds and their opponents combined to hit the over on the total three times (all 10 games had set totals).
• The Reds have a 6-4-0 record against the spread over their past 10 games.

Reds Recent Stats

Reds Player Insights

• Not only does Elly De La Cruz lead the Reds in hitting with his .263 average, he also is their premier power option with 19 home runs and 82 RBI.
• Of all hitters in the majors, De La Cruz's home run total ranks him 80th, and his RBI tally puts him 31st.
• TJ Friedl is batting .261 with 20 doubles, two triples, 12 home runs and 75 walks.
• Friedl ranks 164th in homers and 174th in RBI among all hitters in the majors.
• Spencer Steer is batting .237 with 20 doubles, two triples, 17 home runs and 45 walks.
• Austin Hays is batting .266 with 15 doubles, five triples, 15 home runs and 29 walks.

Reds Team Props

Cardinals Recent Betting Performance

• The Cardinals have played as underdogs in seven of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Cardinals and their opponents are 5-5-0 when it comes to hitting the over.
• Over their last 10 games, the Cardinals are 3-7-0 against the spread.

Cardinals Recent Stats

Cardinals Player Insights

• Alec Burleson is batting .281 with 23 doubles, two triples, 17 home runs and 36 walks, while getting on base at a rate of .333.
• Burleson's home run total places him 101st in the big leagues, and he is 87th in RBI.
• Willson Contreras has hit 20 home runs with 80 runs batted in, leading the team in both categories.
• Contreras is currently 70th in home runs and 37th in RBI in the major leagues.
• Brendan Donovan has racked up a team-best batting average of .283.
• Lars Nootbaar is hitting .238 with 23 doubles, a triple, 13 home runs and 58 walks.

Cardinals Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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