Red Sox vs. White Sox Prediction, Odds, Picks - April 21

Alexander David Bregman and the Boston Red Sox will take on Luis Robert and the Chicago White Sox at Fenway Park on Monday at 11:10 a.m. ET, in the final game of a four-game series. The White Sox are +238 moneyline underdogs in this matchup with the Red Sox (-297). Boston is a 1.5-run favorite (at -139 odds). The matchup's over/under has been set at 9 runs.

Here is everything you need from a betting perspective on the Red Sox-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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White Sox vs. Red Sox Highlights | MLB on FOX

Check out the best highlights between the Chicago White Sox and the Boston Red Sox.

Red Sox vs. White Sox Game Information & Odds

• When: Monday, April 21, 2025 at 11:10 a.m. ET
• Where: Fenway Park in Boston, Massachusetts
• How to watch on TV: NESN and CHSN

Red Sox vs. White Sox Prediction

• Score Prediction: Red Sox 5, White Sox 4
• Total Prediction: Over 9 runs
• Win Probabilities: Red Sox 56%, White Sox 44%

Red Sox vs. White Sox Betting Insights

• This season, the Red Sox have won nine out of the 16 games, or 56.2%, in which they've been favored.
• Boston has played as favorites of -297 or more once this season and won that game.
• The implied probability of a win from the Red Sox, based on the moneyline, is 74.8%.
• The White Sox have been underdogs in 21 games this season and have come away with the win five times (23.8%) in those contests.
• Chicago has played as an underdog of +238 or more just one time this year and came away with a loss in that game.
• Oddsmakers have implied with the moneyline set for this matchup that the White Sox have a 29.6% chance of pulling out a win.

Red Sox Recent Betting Performance

• The Red Sox played as the moneyline favorite in seven of their last 10 games, and finished 4-3 in those matchups.
• In their last 10 outings (all 10 of them had set totals), the Red Sox and their opponents combined to hit the over five times.
• The Red Sox's record against the spread is 4-6-0 over their past 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Bregman has racked up a team-best 16 runs batted in.
• Of all hitters in MLB, Bregman is 40th in home runs and 18th in RBI.
• Wilyer Abreu is batting .286 with five doubles, four home runs and 14 walks.
• Abreu is 40th in homers in MLB, and 24th in RBI.
• Trevor Story leads the Red Sox with five home runs while racking up a team-high batting average of .318.
• Story has at least one base hit in two straight games. During his last five outings he is hitting .350 with two home runs, a walk and six RBI.
• Kristian Campbell is batting .301 with five doubles, three home runs and 13 walks.
• Campbell brings a two-game streak with at least one hit into this one. In his last five games he is batting .278 with a double, a home run, three walks and an RBI.

Red Sox Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and have gone 3-7 in those contests.
• In their last 10 games with a total, the White Sox and their opponents have combined to hit the over four times.
• The White Sox have four wins against the spread in their last 10 chances.

White Sox Recent Stats

White Sox Player Insights

• Robert has a double, two home runs and 12 walks while batting .154.
• In all of the big leagues, Robert ranks 116th in homers and 177th in RBI.
• Andrew Sebastian Benintendi's three home runs pace his team.
• Benintendi is currently 72nd in homers and 155th in RBI in the big leagues.
• Matt Thaiss is batting .229 with two doubles, a home run and nine walks.
• Brooks Baldwin has driven in the most runs for the White Sox with 10 runs batted in.

White Sox Team Props

White Sox vs. Red Sox Highlights | MLB on FOX

Check out the best highlights between the Chicago White Sox and the Boston Red Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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