Red Sox vs. Orioles Prediction, Odds, Picks - May 25

Rafael Devers and Ryan O'Hearn will be among the star attractions when the Boston Red Sox face the Baltimore Orioles on Sunday at 1:35 p.m. ET, at Fenway Park. The favored Red Sox have -130 moneyline odds against the underdog Orioles, who are listed at +110. Boston (-1.5) is favored on the run line. The over/under for the game is set at 9 runs.

Check out everything you need to know from a betting perspective on the Red Sox-Orioles game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Orioles vs. Red Sox Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the Boston Red Sox.

Red Sox vs. Orioles Game Information & Odds

• When: Sunday, May 25, 2025 at 1:35 p.m. ET
• Where: Fenway Park in Boston, Massachusetts
• How to watch on TV: MLB Network, NESN, and MASN

Red Sox vs. Orioles Prediction

• Score Prediction: Red Sox 5, Orioles 3
• Total Prediction: Under 9 runs
• Win Probabilities: Red Sox 59%, Orioles 41%

Red Sox vs. Orioles Betting Insights

• The Red Sox have been favorites in 37 games this season and won 19 (51.4%) of those contests.
• This season Boston has won eight of its 19 games, or 42.1%, when favored by at least -130 on the moneyline.
• The Red Sox have a 56.5% chance to win this game based on the implied probability of the moneyline.
• The Orioles have been chosen as underdogs in 22 games this year and have walked away with the win eight times (36.4%) in those games.
• Baltimore has a mark of 2-7 in contests where bookmakers favor it by +110 or worse on the moneyline.
• The moneyline set for this matchup implies the Orioles have a 47.6% chance of coming away with a victory in the contest.

Red Sox Recent Betting Performance

• The Red Sox went 2-3 across the five games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 outings (all 10 of them had set totals), the Red Sox and their opponents combined to hit the over five times.
• The Red Sox's ATS record is 6-4-0 over their past 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Devers has gone yard 12 times in the 2025 campaign while knocking in 48 runs, both totals that lead the Red Sox.
• Devers ranks 13th in homers and first in RBI among all batters in baseball.
• Jarren Duran is hitting .268 with 12 doubles, six triples, four home runs and 15 walks.
• Duran ranks 151st in home runs and 22nd in RBI in the bigs.
• Wilyer Abreu has a team-high 12 home runs.
• Abreu will look to build on his two-game hitting in this game. During his last five outings he is hitting .235 with a double, a home run, a walk and an RBI.
• Ceddanne Rafaela is batting .226 with eight doubles, two triples, two home runs and 10 walks.

Red Sox Team Props

Orioles Recent Betting Performance

• The Orioles have played as underdogs in five of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Orioles and their opponents have failed to hit the over four times.
• The Orioles have a record of 2-8-0 ATS over their last 10 games.

Orioles Recent Stats

Orioles Player Insights

• Cedric Mullins has posted a team-high 10 home runs and has driven in 31 runs.
• Mullins is 24th in home runs and 24th in RBI among all hitters in the big leagues.
• O'Hearn has a club-high .315 batting average.
• O'Hearn is 71st in homers and 158th in RBI among all batters in the big leagues.
• Adley Rutschman has seven doubles, a triple, five home runs and 24 walks while hitting .214.
• Gunnar Henderson is hitting .263 with 10 doubles, two triples, seven home runs and 14 walks.

Orioles Team Props

Orioles vs. Red Sox Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the Boston Red Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.