Red Sox vs. Athletics Prediction, Odds, Picks - September 16

Connelly Early will take the mound first for the Boston Red Sox on Tuesday against Tyler Soderstrom and the Athletics. First pitch is at 6:45 p.m. ET for this first game in a three-game series. Oddsmakers list the Red Sox as -161 moneyline favorites, while giving the underdog Athletics +135 moneyline odds to win. The Red Sox are a 1.5-run favorite (at +130 odds). The total for the game is set at 8.5 runs.

Take a look at everything you need to know from a betting perspective on the Red Sox-Athletics game, regarding the run line, moneyline and total, plus expert picks.

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Pirates vs. Red Sox Highlights | MLB on FOX

Check out the best moments between the Pittsburgh Pirates and Boston Red Sox.

Red Sox vs. Athletics Game Information & Odds

• When: Tuesday, September 16, 2025 at 6:45 p.m. ET
• Where: Fenway Park in Boston, Massachusetts
• How to watch on TV: NESN and NBCS-CA

Red Sox vs. Athletics Prediction

• Score Prediction: Red Sox 3, Athletics 2
• Total Prediction: Under 8.5 runs
• Win Probabilities: Red Sox 62%, Athletics 38%

Red Sox vs. Athletics Betting Insights

• The Red Sox have entered the game as favorites 92 times this season and won 54, or 58.7%, of those games.
• The Red Sox have a record of 19-11, a 63.3% win rate, when they're favored by -161 or more by bookmakers this season.
• The oddsmakers' moneyline implies a 61.7% chance of a victory for the Red Sox.
• The Athletics have come away with 53 wins in the 113 contests they have been listed as the underdogs in this season.
• This year, the Athletics have won 14 of 43 games when listed as at least +135 or better on the moneyline.
• The moneyline set for this matchup implies the Athletics have a 42.6% chance of coming away with a victory in the contest.

Red Sox Recent Betting Performance

• The Red Sox have a 2-4 record across the six games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups, the Red Sox and their opponents combined to go over the run total three times (all 10 of the games had set totals).
• The Red Sox's record against the spread is 4-6-0 over their past 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Jarren Duran gets on base at a .333 clip while slugging .449, both marks that lead the Red Sox. He also has the team high in hits with 148.
• Duran ranks 129th in homers and 37th in RBI among all hitters in the majors.
• Duran carries a two-game hitting streak into this matchup. In his last five games he is batting .235 with two doubles, a triple, a home run and two RBIs.
• Trevor Story has shown off his power as he paces his team with 24 home runs and 91 runs batted in, with a team-leading .261 batting average.
• Of all major league hitters, Story is 47th in homers and 18th in RBI.
• Alex Bregman has 27 doubles, 17 home runs and 43 walks while hitting .278.
• Bregman has at least one base hit in six games in a row. In his last 10 games he is batting .220 with two doubles, a home run, four walks and five RBIs.
• Ceddanne Rafaela is batting .239 with 29 doubles, three triples, 16 home runs and 25 walks.

Red Sox Team Props

Athletics Recent Betting Performance

• The Athletics have played as underdogs in seven of their past 10 games and won five of those contests.
• In their last 10 games with a total, the Athletics and their opponents have combined to hit the over four times.
• The Athletics are 6-4-0 ATS over their last 10 games.

Athletics Recent Stats

Athletics Player Insights

• Brent Rooker is batting .269 with 40 doubles, three triples, 29 home runs and 59 walks, while getting on base at a rate of .339.
• Rooker's home run total puts him 21st in the big leagues, and he is 28th in RBI.
• Rooker has collected a hit in four straight games. In his last five games he is batting .333 with two doubles, two home runs, two walks and three RBIs.
• Soderstrom has driven in the most runs for the Athletics with 88 runs batted in.
• Soderstrom ranks 47th in homers and 22nd in RBI among all major league hitters this year.
• Nick Kurtz has 32 home runs, best in the lineup.
• Shea Langeliers is hitting .264 with 28 doubles, 30 home runs and 35 walks.

Athletics Team Props

Pirates vs. Red Sox Highlights | MLB on FOX

Check out the best moments between the Pittsburgh Pirates and Boston Red Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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