Rays vs. Guardians Prediction, Odds, Picks - September 5

Jose Ramirez and the Cleveland Guardians take the field on Friday at George M. Steinbrenner Field against Griffin Jax, who gets the start for the Tampa Bay Rays. First pitch is at 7:35 p.m. ET. The favored Rays have -152 moneyline odds against the underdog Guardians, who are listed at +127. Tampa Bay is the run-line favorite (-1.5). A 7.5-run total has been listed in this matchup.

Take a look at everything you need from a betting perspective on the Rays-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Rays vs. Guardians Game Information & Odds

• When: Friday, September 5, 2025 at 7:35 p.m. ET
• Where: George M. Steinbrenner Field in Tampa, Florida
• How to watch on TV: FDSSUN and CLEG

Rays vs. Guardians Prediction

• Score Prediction: Rays 5, Guardians 3
• Total Prediction: Over 7.5 runs
• Win Probabilities: Rays 62%, Guardians 38%

Rays vs. Guardians Betting Insights

• This season, the Rays have won 42 out of the 69 games, or 60.9%, in which they've been favored.
• Tampa Bay has a record of 9-12, a 42.9% win rate, when favored by -152 or more by sportsbooks this season.
• The implied probability of a win from the Rays, based on the moneyline, is 60.3%.
• The Guardians have been chosen as underdogs in 79 games this year and have walked away with the win 34 times (43%) in those games.
• This year, Cleveland has won 14 of 30 games when listed as at least +127 or worse on the moneyline.
• The Guardians have an implied victory probability of 44.1% according to the moneyline set for this matchup.

Rays Recent Betting Performance

• The Rays went 5-1 over the six games they were favored on the moneyline in their last 10 matchups.
• In their last 10 outings, the Rays and their opponents combined to go over the run total five times (all 10 of the games had set totals).
• The Rays are 8-2-0 against the spread over their past 10 games.

Rays Recent Stats

Rays Player Insights

• The Rays' best power option comes in the form of Junior Caminero and his 40-dinger 102-RBI season, both team highs.
• Among all MLB hitters, Caminero ranks 65th in batting average, 126th in on-base percentage, and ninth in slugging.
• Caminero has collected a hit in four games in a row. During his last five outings he is hitting .429 with three doubles, a home run and eight RBIs.
• Yandy Diaz's .292 batting average leads his team.
• Diaz ranks 48th in homers and 40th in RBI on the year.
• Brandon Lowe is batting .265 with 15 doubles, 28 home runs and 35 walks.
• Lowe has at least one base hit in eight straight games. During his last 10 games he is batting .250 with two doubles, three home runs, four walks and 11 RBIs.
• Chandler Simpson has 11 doubles, three triples and 18 walks while hitting .290.

Rays Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs in eight of their past 10 games and won four of those contests.
• When it comes to hitting the over, the Guardians and their opponents are 4-4-2 in their last 10 games with a total.
• The Guardians have a record of 5-5-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez leads the squad with a batting average of .280, and leads the Guardians in home runs, with 27 and runs batted in with 71.
• Ramirez's home run total puts him 24th in the majors, and he ranks 54th in RBI.
• Steven Kwan is batting .272 with 25 doubles, a triple, 10 home runs and 45 walks.
• Kwan is 183rd among all hitters in MLB in homers, and 177th in RBI.
• Kyle Manzardo has 14 doubles, two triples, 25 home runs and 43 walks while hitting .232.
• Angel Martinez is hitting .225 with 21 doubles, a triple, 10 home runs and 17 walks.

Guardians Team Props

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Tampa Bay Rays

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