Pirates vs. Cubs Prediction, Odds, Picks - September 16

The Pittsburgh Pirates and Chicago Cubs will send Paul Skenes and Cade Horton, respectively, out to start when the two squads square off on Tuesday at PNC Park, at 6:40 p.m. ET. The Cubs are +110 moneyline underdogs in this matchup with the Pirates (-131). Pittsburgh (-1.5) is favored on the run line. The over/under is 6.5 runs for this matchup (with -116 odds to hit the over and -105 odds on the under).

Take a look at everything you need to know from a betting perspective on the Pirates-Cubs game, regarding the run line, moneyline and total, plus expert picks.

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Pirates vs. Cubs Game Information & Odds

• When: Tuesday, September 16, 2025 at 6:40 p.m. ET
• Where: PNC Park in Pittsburgh, Pennsylvania
• How to watch on TV: SportsNet PT and MARQ

Pirates vs. Cubs Prediction

• Score Prediction: Cubs 4, Pirates 3
• Total Prediction: Over 6.5 runs
• Win Probabilities: Pirates 52%, Cubs 48%

Pirates vs. Cubs Betting Insights

• This season, the Pirates have won 21 out of the 43 games, or 48.8%, in which they've been favored.
• Pittsburgh is 11-11 this season when entering a game favored by -131 or more on the moneyline.
• The moneyline for this contest implies a 56.7% chance of a victory for the Pirates.
• The Cubs have been chosen as underdogs in 41 games this year and have walked away with the win 17 times (41.5%) in those games.
• Chicago has a win-loss record of 6-10 when favored by +110 or worse by oddsmakers this year.
• The Cubs have an implied victory probability of 47.6% according to the moneyline set by sportsbooks for this matchup.

Pirates Recent Betting Performance

• The Pirates have a 1-3 record across the four games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 matchups, the Pirates and their opponents combined to go over the run total two times (all 10 games had set totals).
• The Pirates' ATS record is 3-7-0 over their past 10 games.

Pirates Recent Stats

Pirates Player Insights

• Bryan Reynolds is the Pirates best hitter, putting together an average of .243 while also being the team's top run producer, delivering 71 RBI and crushing 15 homers.
• Reynolds' home runs rank him 129th in the majors, and he ranks 69th in RBI.
• Andrew McCutchen has 22 doubles, 13 home runs and 63 walks while hitting .239.
• McCutchen is 154th in home runs and 130th in RBI in the major leagues.
• Oneil Cruz has a team-best 19 home runs.
• Spencer Horwitz has 22 doubles, nine home runs and 37 walks while hitting .260.
• Horwitz is riding a two-game hitting streak into this one. In his last five games he is batting .333 with a double, a home run, three walks and two RBIs.

Pirates Team Props

Cubs Recent Betting Performance

• Over the past 10 games, the Cubs have been underdogs twice and split those games 1-1.
• In their last 10 games with a total, the Cubs and their opponents are 4-5-1 when it comes to hitting the over.
• Over their last 10 games, the Cubs are 6-4-0 against the spread.

Cubs Recent Stats

Cubs Player Insights

• Nico Hoerner paces the Cubs with a .299 batting average.
• Hoerner's home run total puts him 269th in the big leagues, and he is 114th in RBI.
• Hoerner takes a hitting streak of 10 games into this game. In his last 10 games he is hitting .436 with five doubles, a triple, a home run, five walks and five RBIs.
• Pete Crow-Armstrong's 29 home runs pace his team.
• Crow-Armstrong is 21st among all batters in MLB in homers, and 22nd in RBI.
• Ian Happ has 28 doubles, 22 home runs and 82 walks while hitting .242.
• Seiya Suzuki has racked up a team-leading 91 runs batted in.

Cubs Team Props

Pirates vs. Nationals Highlights | MLB on FOX

Check out the best moments between the Pittsburgh Pirates and the Washington Nationals!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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