Phillies vs. Red Sox Prediction, Odds, Picks - July 22

Bryce Harper and the Philadelphia Phillies head into the second of a three-game series against Romy Gonzalez and the Boston Red Sox at Citizens Bank Park, Tuesday at 6:45 p.m. ET. Oddsmakers list the Phillies as -190 favorites on the moneyline, while giving the underdog Red Sox +157 moneyline odds. Philadelphia is a 1.5-run favorite (at +109 odds). The over/under is 8.5 runs for this contest (with -102 odds to go over and -118 odds to go under).

Take a look at everything you need to know from a betting perspective on the Phillies-Red Sox game, regarding the run line, moneyline and total, plus expert picks.

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Red Sox vs. Phillies Highlights | MLB on FOX

Check out the best moments between the Boston Red Sox and the Philadelphia Phillies.

Phillies vs. Red Sox Game Information & Odds

• When: Tuesday, July 22, 2025 at 6:45 p.m. ET
• Where: Citizens Bank Park in Philadelphia, Pennsylvania
• How to watch on TV: TBS, NBCS-PH, and NESN

Phillies vs. Red Sox Prediction

• Score Prediction: Phillies 4, Red Sox 3
• Total Prediction: Under 8.5 runs
• Win Probabilities: Phillies 53%, Red Sox 47%

Phillies vs. Red Sox Betting Insights

• The Phillies have entered the game as favorites 79 times this season and won 50, or 63.3%, of those games.
• Philadelphia has a record of 20-3 in games when sportsbooks favor them by at least -190 on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Phillies have a 65.5% chance to win.
• The Red Sox have won in 15, or 41.7%, of the 36 contests they have been named as odds-on underdogs this year.
• This year, Boston has won one of four games when listed as at least +157 or worse on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Red Sox have a 38.9% chance of pulling out a win.

Phillies Recent Betting Performance

• The Phillies have a 4-5 record over the nine games they were favored on the moneyline in their last 10 matchups.
• In their last 10 matchups, the Phillies and their opponents combined to hit the over on the total five times (all 10 games had set totals).
• The Phillies are 3-7-0 against the spread over their past 10 games.

Phillies Recent Stats

Phillies Player Insights

• Kyle Schwarber is the Phillies best power hitter, hitting 32 round-trippers this season in addition to collecting 74 RBI, both team highs.
• Including all MLB hitters, Schwarber ranks 105th in batting average, 14th in on-base percentage, and 10th in slugging.
• Trea Turner has a club-high .286 batting average.
• Among all major league hitters, Turner is 111th in homers and 99th in RBI.
• Harper has 22 doubles, 13 home runs and 44 walks while hitting .271.
• Nick Castellanos is batting .270 with 22 doubles, a triple, 12 home runs and 22 walks.

Phillies Team Props

Red Sox Recent Betting Performance

• The Red Sox have played as underdogs three times over their past 10 games and lost each of those contests.
• The Red Sox and their opponents have combined to hit the over three times in their last 10 games with a total.
• The Red Sox are 7-3-0 ATS over their last 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Ceddanne Rafaela leads the Red Sox with a team-leading batting average of .270.
• In all of MLB, Rafaela is 63rd in homers and 69th in RBI.
• Jarren Duran is hitting .257 with 25 doubles, 10 triples, nine home runs and 34 walks.
• Duran is 145th in home runs and 56th in RBI among all MLB batters this season.
• Wilyer Abreu has 20 home runs, tops in the clubhouse.
• Trevor Story has sent home a team-high 59 runs batted in.

Red Sox Team Props

Red Sox vs. Phillies Highlights | MLB on FOX

Check out the best moments between the Boston Red Sox and the Philadelphia Phillies.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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