Padres vs. Twins Prediction, Odds, Picks - August 29

Zebby Matthews will look to shut down Fernando Tatis Jr. and the San Diego Padres when they square off against his Minnesota Twins on Friday at 8:10 p.m. ET. The Padres are -125 moneyline favorites for this matchup with the Twins (+106). San Diego (-1.5) is favored on the run line. The over/under is 8.5 runs for this contest.

Here's everything you need to know from a betting perspective on the Padres-Twins game, regarding the run line, moneyline and total, plus expert picks.

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Twins vs. Blue Jays Highlights | MLB on FOX

Check out the best moments between the Minnesota Twins and the Toronto Blue Jays.

Padres vs. Twins Game Information & Odds

• When: Friday, August 29, 2025 at 8:10 p.m. ET
• Where: Target Field in Minneapolis, Minnesota
• How to watch on TV: MNNT and SDPA

Padres vs. Twins Prediction

• Score Prediction: Padres 6, Twins 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Padres 51%, Twins 49%

Padres vs. Twins Betting Insights

• The Padres have entered the game as favorites 70 times this season and won 43, or 61.4%, of those games.
• San Diego has a record of 36-22 in games when bookmakers favor them by at least -125 on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Padres have a 55.6% chance to win.
• The Twins have been chosen as underdogs in 53 games this year and have walked away with the win 20 times (37.7%) in those games.
• Minnesota has a mark of 12-21 in contests where sportsbooks favor it by +106 or worse on the moneyline.
• The Twins have an implied victory probability of 48.5% according to the moneyline set by oddsmakers for this matchup.

Padres Recent Betting Performance

• The Padres played as the moneyline favorite in four of their last 10 games, and finished 3-1 in those matchups.
• In their last 10 matchups, the Padres and their opponents combined to hit the over on the run total five times (all 10 games had set totals).
• The Padres' record against the spread is 6-4-0 over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Tatis is hitting .264 with 27 doubles, two triples, 18 home runs and 79 walks.
• Among all MLB hitters, Tatis ranks 63rd in batting average, 14th in on-base percentage, and 77th in slugging.
• Tatis has collected a hit in three straight games. During his last five outings he is batting .200 with two doubles, a home run, three walks and three RBIs.
• Manny Machado's 21 home runs, 78 runs batted in and .288 batting average are all team-highs.
• Machado ranks 49th in home runs and 23rd in RBI on the year.
• Luis Arraez has 29 doubles, four triples, six home runs and 26 walks while batting .283.
• Xander Bogaerts has 29 doubles, 10 home runs and 48 walks while hitting .262.
• Bogaerts takes a three-game streak with at least one hit into this one. In his last five games he is batting .235 with a double, a walk and three RBIs.

Padres Team Props

Twins Recent Betting Performance

• The Twins have played as underdogs in five of their past 10 games and won two of those contests.
• The Twins and their opponents have combined to hit the over seven times in their last 10 games with a total.
• The Twins have won four of their last 10 games against the spread.

Twins Recent Stats

Twins Player Insights

• Byron Buxton paces the Twins with 27 home runs and 64 runs batted in, while recording a team-best batting average of .269.
• Among all hitters in the big leagues, Buxton's home run total ranks 16th and his RBI tally ranks 66th.
• Trevor Larnach has 19 doubles, a triple, 16 home runs and 45 walks while hitting .242.
• Larnach is currently 92nd in homers and 124th in RBI in the major leagues.
• Brooks Lee is hitting .249 with 13 doubles, a triple, 14 home runs and 25 walks.
• Ryan Jeffers has 23 doubles, nine home runs and 43 walks while batting .258.

Twins Team Props

Twins vs. Blue Jays Highlights | MLB on FOX

Check out the best moments between the Minnesota Twins and the Toronto Blue Jays.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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