Padres vs. Diamondbacks Prediction, Odds, Picks - August 5

The San Diego Padres versus Arizona Diamondbacks game on Tuesday at 9:40 p.m. ET will showcase a pair of hot hitters in Manny Machado and Geraldo Perdomo. The Padres are the favorite in this one, at -132, while the underdog Diamondbacks have +111 odds to upset. San Diego is the favorite on the run line (-1.5 with +120 odds). The total is 9 runs for the contest (with -103 odds to hit the over and -117 odds on the under).

Here is everything you need from a betting perspective on the Padres-Diamondbacks game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Padres vs. Diamondbacks Highlights | MLB on FOX

Check out the best moments from this MLB matchup between the San Diego Padres and the Arizona Diamondbacks.

Padres vs. Diamondbacks Game Information & Odds

• When: Tuesday, August 5, 2025 at 9:40 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: MLB Network, ARID, and SDPA

Padres vs. Diamondbacks Prediction

• Score Prediction: Diamondbacks 5, Padres 4
• Total Prediction: Under 9 runs
• Win Probabilities: Padres 52%, Diamondbacks 48%

Padres vs. Diamondbacks Betting Insights

• The Padres have won 35, or 58.3%, of the 60 games they've played as favorites this season.
• San Diego is 26-16 this season when entering a game favored by -132 or more on the moneyline.
• The implied probability of a win from the Padres, based on the moneyline, is 56.9%.
• The Diamondbacks have been chosen as underdogs in 44 games this year and have walked away with the win 20 times (45.5%) in those games.
• Arizona has a mark of 12-9 in contests where bookmakers favor it by +111 or worse on the moneyline.
• The moneyline set for this matchup implies the Diamondbacks have a 47.4% chance of coming away with a victory in the contest.

Padres Recent Betting Performance

• The Padres played as the moneyline favorite in seven of their last 10 games, and finished 4-3 in those matchups.
• In their last 10 matchups, the Padres and their opponents combined to hit the over on the run total four times (all 10 games had set totals).
• The Padres' ATS record is 6-4-0 over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Not only does Machado lead the Padres in hitting with his .299 average, he also paces the squad with 20 home runs and 72 RBI.
• Among all batters in MLB, Machado's home run total places him 28th, and his RBI tally ranks him 17th.
• Fernando Tatis Jr. is hitting .264 with 19 doubles, two triples, 17 home runs and 64 walks.
• Of all MLB hitters, Tatis ranks 56th in homers and 114th in RBI.
• Tatis carries a two-game streak with at least one hit into this contest. In his last five games he is batting .167 with a double and five walks.
• Luis Arraez is hitting .296 with 21 doubles, four triples, six home runs and 23 walks.
• Xander Bogaerts is batting .267 with 24 doubles, seven home runs and 44 walks.

Padres Team Props

Diamondbacks Recent Betting Performance

• In eight games over the last 10 matchups when set as underdogs by bookmakers, the Diamondbacks had a record of 3-5.
• When it comes to hitting the over, the Diamondbacks and their opponents are 1-7-2 in their last 10 games with a total.
• The Diamondbacks have three wins against the spread in their last 10 chances.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Perdomo has driven in a team-leading 75 runs batted in.
• Among all hitters in MLB, Perdomo ranks 125th in home runs and 11th in RBI.
• Corbin Carroll has a team-high 22 home runs.
• Carroll ranks 20th in home runs and 61st in RBI among all MLB hitters this season.
• Ketel Marte paces the Diamondbacks with a team-best batting average of .291.
• Lourdes Gurriel Jr. is hitting .247 with 21 doubles, two triples, 12 home runs and 26 walks.

Diamondbacks Team Props

Padres vs. Diamondbacks Highlights | MLB on FOX

Check out the best moments from this MLB matchup between the San Diego Padres and the Arizona Diamondbacks.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Arizona Diamondbacks

San Diego Padres