Padres vs. Cardinals Prediction, Odds, Picks - August 1

Willson Contreras and the St. Louis Cardinals hit the field on Friday at PETCO Park against Nick Pivetta, who is the named starter for the San Diego Padres. First pitch will be at 9:40 p.m. ET. The Cardinals have been listed as +170 moneyline underdogs for this matchup with the favored Padres (-205). San Diego is the favorite on the run line (-1.5). A 7.5-run total is listed for the matchup.

Here's everything you need from a betting perspective on the Padres-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Marlins vs. Cardinals Highlights | MLB on FOX

Check out the best moments between the Miami Marlins and the St. Louis Cardinals.

Padres vs. Cardinals Game Information & Odds

• When: Friday, August 1, 2025 at 9:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and FDSMW

Padres vs. Cardinals Prediction

• Score Prediction: Padres 4, Cardinals 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Padres 55%, Cardinals 45%

Padres vs. Cardinals Betting Insights

• This season, the Padres have been favored 56 times and won 33, or 58.9%, of those games.
• San Diego has entered seven games this season favored by -205 or more and is 4-3 in those contests.
• Bookmakers have implied with the moneyline set for this matchup that the Padres have a 67.2% chance to win.
• The Cardinals have been underdogs in 55 games this season and have come away with the win 27 times (49.1%) in those contests.
• St. Louis has won all of its three games in which it was named as at least a +170 moneyline underdog.
• The Cardinals have an implied victory probability of 37% according to the moneyline set by sportsbooks for this matchup.

Padres Recent Betting Performance

• The Padres were favored on the moneyline for four of their last 10 games, and they went 2-2 in those matchups.
• Over their last 10 matchups, the Padres and their opponents combined to hit the over three times (all 10 of the games had set totals).
• The Padres are 6-4-0 against the spread over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Manny Machado leads the Padres in home runs (20), runs batted in (71) and has a team-high batting average of .302.
• Among all hitters in the majors, Machado's home run total ranks him 24th, and his RBI tally puts him 14th.
• Machado brings a hitting streak of eight games into this game. During his last 10 outings he is hitting .429 with four doubles, two home runs and 11 RBIs.
• Fernando Tatis Jr. is hitting .269 with 18 doubles, two triples, 17 home runs and 60 walks.
• Tatis ranks 52nd in home runs and 100th in RBI on the season.
• Tatis enters this game looking for his fifth game in a row with a hit. In his last five games he is batting .278 with two doubles, five walks and an RBI.
• Luis Arraez has 20 doubles, four triples, six home runs and 22 walks while batting .295.
• Arraez will look to build on his 13-game hitting in this game. In his last 10 outings he is hitting .400 with three doubles, a home run, three walks and five RBIs.
• Xander Bogaerts is batting .267 with 24 doubles, seven home runs and 44 walks.

Padres Team Props

Cardinals Recent Betting Performance

• The Cardinals have been underdogs once in the past 10 games and won that contest.
• When it comes to hitting the over, the Cardinals and their opponents are 2-6-2 in their last 10 games with a total.
• The Cardinals are 4-6-0 ATS over their last 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Brendan Donovan is batting .285 with 24 doubles, nine home runs and 39 walks, while getting on base at a rate of .358.
• Donovan's home run total places him 155th in MLB, and he ranks 122nd in RBI.
• Alec Burleson's 14 home runs and .287 batting average both pace his club.
• Burleson ranks 86th in homers and 82nd in RBI among all MLB batters this year.
• Contreras has been a significant run producer for the Cardinals with 14 home runs and 61 runs batted in.
• Masyn Winn is batting .270 with 23 doubles, seven home runs and 27 walks.

Cardinals Team Props

Marlins vs. Cardinals Highlights | MLB on FOX

Check out the best moments between the Miami Marlins and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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San Diego Padres

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