Orioles vs. Cardinals Prediction, Odds, Picks - May 28

Brendan Donovan and the St. Louis Cardinals take the field on Wednesday at Oriole Park at Camden Yards against Cade Povich, who is the named starter for the Baltimore Orioles. First pitch is set for 6:35 p.m. ET. The favored Orioles have -118 moneyline odds to win against the underdog Cardinals, who are listed at -101. St. Louis (-1.5) is the favorite on the run line. An 8-run over/under has been set for the game.

Here's everything you need from a betting perspective on the Orioles-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Orioles vs. Cardinals Game Information & Odds

• When: Wednesday, May 28, 2025 at 6:35 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: MLB Network, MASN, and FDSMW

Orioles vs. Cardinals Prediction

• Score Prediction: Cardinals 6, Orioles 5
• Total Prediction: Over 8 runs
• Win Probabilities: Orioles 54%, Cardinals 46%

Orioles vs. Cardinals Betting Insights

• The Orioles have entered the game as favorites 28 times this season and won nine, or 32.1%, of those games.
• Baltimore is 9-15 this season when entering a game favored by -118 or more on the moneyline.
• The bookmakers' moneyline implies a 54.1% chance of a victory for the Orioles.
• The Cardinals have won in 19, or 55.9%, of the 34 contests they have been named as odds-on underdogs this year.
• St. Louis has a mark of 10-12 in contests where bookmakers favor it by -101 or worse on the moneyline.
• The moneyline set for this matchup implies the Cardinals have a 50.2% chance of coming away with a victory in the contest.

Orioles Recent Betting Performance

• The Orioles have been named the moneyline favorite by oddsmakers only one time in the last 10 games, and lost that matchup.
• Over their last 10 outings, the Orioles and their opponents combined to go over the run total six times (all 10 of the games had set totals).
• The Orioles' ATS record is 4-6-0 over their past 10 games.

Orioles Recent Stats

Orioles Player Insights

• Ryan O'Hearn is the Orioles best hitter so far this season, hitting at a team-leading .340 clip along with nine homers and 21 RBI.
• O'Hearn's home runs put him 45th in MLB, and he is 117th in RBI.
• O'Hearn has collected a hit in seven straight games. During his last 10 games he is batting .486 with three doubles, two home runs, five walks and seven RBIs.
• Cedric Mullins has hit 10 home runs with 31 runs batted in. Both lead his team.
• Among all major league batters, Mullins is 29th in home runs and 33rd in RBI.
• Gunnar Henderson is batting .261 with 10 doubles, two triples, seven home runs and 18 walks.
• Adley Rutschman is batting .211 with seven doubles, a triple, five home runs and 24 walks.

Orioles Team Props

Cardinals Recent Betting Performance

• The Cardinals have played as underdogs in three of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Cardinals and their opponents are 4-6-0 when it comes to hitting the over.
• The Cardinals have won five of their last 10 games against the spread.

Cardinals Recent Stats

Cardinals Player Insights

• Lars Nootbaar has a team-best eight home runs.
• Among all hitters in MLB, Nootbaar ranks 55th in home runs and 68th in RBI.
• Donovan's .328 batting average paces his team.
• Donovan ranks 194th overall in home runs and 110th in RBI this season.
• Nolan Arenado is hitting .238 with 10 doubles, a triple, six home runs and 18 walks.
• Masyn Winn is batting .261 with six doubles, six home runs and 18 walks.

Cardinals Team Props

Red Sox's Rafael Devers smacks a walk-off RBI single vs. Orioles

The Boston Red Sox's Rafael Devers smacked a walk-off RBI single vs. the Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Baltimore Orioles

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