Nationals vs. White Sox Prediction, Odds, Picks - September 28

Shane Smith takes the mound for the Chicago White Sox on Sunday at Nationals Park against Josh Bell and the Washington Nationals. First pitch is at 3:05 p.m. ET. The Nationals are the favorite in this one, at -116, while the underdog White Sox have -104 odds to win. Chicago is the favorite on the run line (-1.5 with +161 odds). The over/under is 8.5 runs for the matchup (with -102 odds to go over and -119 odds on the under).

Take a look at everything you need from a betting perspective on the Nationals-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Nationals vs. White Sox Game Information & Odds

• When: Sunday, September 28, 2025 at 3:05 p.m. ET
• Where: Nationals Park in Washington D.C.
• How to watch on TV: MASN2 and CHSN

Nationals vs. White Sox Prediction

• Score Prediction: Nationals 6, White Sox 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Nationals 50%, White Sox 50%

Nationals vs. White Sox Betting Insights

• This season, the Nationals have won seven out of the 20 games, or 35%, in which they've been favored.
• Washington has entered 15 games this season favored by -116 or more and is 3-12 in those contests.
• The implied probability of a win from the Nationals, based on the moneyline, is 53.7%.
• The White Sox have come away with 58 wins in the 158 contests they have been listed as the underdogs in this season.
• This season, Chicago has come away with a win 57 times in 155 chances when named as an underdog of at least -104 or worse on the moneyline.
• The moneyline set for this matchup implies the White Sox have a 51% chance of coming away with a victory in the contest.

Nationals Recent Betting Performance

• The Nationals were listed as the moneyline favorite by oddsmakers just twice over the last 10 games, and split those matchups.
• In their last 10 outings (all had set totals), the Nationals combined with their opponents to hit the over on the run total five times.
• The Nationals' ATS record is 5-5-0 over their past 10 games.

Nationals Recent Stats

Nationals Player Insights

• James Wood leads the Nationals with 31 home runs and 94 runs batted in.
• Wood is 19th in home runs and 22nd in RBI among all hitters in MLB.
• C.J. Abrams' .258 batting average is a team-high mark.
• Abrams is 94th in homers in the majors, and 130th in RBI.
• Luis Garcia has 28 doubles, a triple, 16 home runs and 27 walks while batting .254.
• Bell is hitting .240 with 17 doubles, a triple, 22 home runs and 57 walks.
• Bell has recorded at least one hit in three straight games. In his last five games he is hitting .500 with three doubles, two home runs, two walks and two RBIs.

Nationals Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in nine of their past 10 games and have gone 2-7 in those contests.
• In their last 10 games with a total, the White Sox and their opponents are 5-5-0 when it comes to hitting the over.
• The White Sox have five wins against the spread in their last 10 chances.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas is batting .234 with 32 doubles, two triples, 15 home runs and 55 walks, while getting on base at a rate of .316.
• Vargas is 141st in home runs and 134th in RBI among all batters in the majors.
• Vargas carries an eight-game hitting streak into this matchup. During his last 10 outings he is batting .270 with a double, a home run, five walks and five RBIs.
• Lenyn Sosa has hit 22 home runs with 75 runs batted in while hitting .263. Those numbers are pace the clubhouse.
• Sosa is currently 65th in homers and 67th in RBI in the major leagues.
• Chase Meidroth is batting .256 with 15 doubles, five home runs and 45 walks.
• Colson Montgomery is hitting .239 with nine doubles, a triple, 21 home runs and 24 walks.

White Sox Team Props

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Enjoy the best moments between the Chicago White Sox and the New York Yankees.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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