Guardians vs. White Sox Prediction, Odds, Picks - July 11

Updated Jul. 11, 2025 5:01 p.m. ET

Data Skrive

Steven Kwan and the Cleveland Guardians hit the field against Mike Tauchman and the Chicago White Sox at Rate Field on Friday, at 8:10 p.m. ET. The Guardians are -127 moneyline favorites in this matchup with the White Sox (+106). Cleveland is the run-line favorite (-1.5). The contest's total has been set at 8 runs.

Here's everything you need to know from a betting perspective on the Guardians-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. White Sox Game Information & Odds

When: Friday, July 11, 2025 at 8:10 p.m. ET
Where: Rate Field in Chicago, Illinois
How to watch on TV: CHSN and CLEG

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Guardians	-127	+106	8	-115	-106	-1.5	+130	-156

Guardians vs. White Sox Prediction

Score Prediction: White Sox 5, Guardians 4
Total Prediction: Over 8 runs
Win Probabilities: Guardians 51%, White Sox 49%

Guardians vs. White Sox Betting Insights

The Guardians have been favorites in 31 games this season and won 18 (58.1%) of those contests.
Cleveland has entered 15 games this season favored by -127 or more and is 11-4 in those contests.
The implied probability of a win from the Guardians, based on the moneyline, is 55.9%.
The White Sox have won in 30, or 33%, of the 91 contests they have been named as odds-on underdogs this year.
This season, Chicago has come away with a win 30 times in 86 chances when named as an underdog of at least +106 or worse on the moneyline.
The moneyline set for this matchup implies the White Sox have a 48.5% chance of coming away with a victory in the contest.

Guardians Recent Betting Performance

In the last 10 games, the Guardians have not been named the moneyline favorite by oddsmakers.
In their last 10 matchups (all had set totals), the Guardians combined with their opponents to go over the run total four times.
The Guardians have gone 7-3-0 against the spread over their past 10 games.

Guardians Recent Stats

Stat	Avg/Total
Record	3-7
Runs Per Game	3.0
HR	11
ERA	3.79
K/9	8.9

Guardians Player Insights

Jose Ramirez is the bat to watch in the Guardians lineup, leading the team in batting average (.301), home runs (17), and RBI (45).
Of all batters in MLB, Ramirez ranks 28th in home runs and 66th in RBI.
Ramirez has collected a hit in three straight games. In his last five games he is hitting .333 with a double, three home runs, four walks and six RBIs.
Kwan is batting .292 with 20 doubles, a triple, six home runs and 30 walks.
Including all major league hitters, Kwan ranks 197th in home runs and 178th in RBI.
Carlos Santana is hitting .230 with seven doubles, 10 home runs and 41 walks.
Kyle Manzardo is batting .217 with 11 doubles, two triples, 13 home runs and 25 walks.

White Sox Recent Betting Performance

The White Sox have played as underdogs in eight of their past 10 games and have gone 3-5 in those contests.
In their last 10 games with a total, the White Sox and their opponents have combined to hit the over two times.
Over their last 10 games, the White Sox are 4-6-0 against the spread.

White Sox Recent Stats

Stat	Avg/Total
Record	4-6
Runs Per Game	3.6
HR	6
ERA	4.32
K/9	6.5

White Sox Player Insights

Miguel Vargas paces the White Sox in home runs (10), runs batted in (34) and has a team-best batting average of .220.
Among all hitters in the majors, Vargas ranks 116th in home runs and 131st in RBI.
Andrew Benintendi has been a reliable source of runs this year, leading the lineup with 10 home runs and 34 runs batted in.
Benintendi is currently 116th in homers and 131st in RBI in the big leagues.
Chase Meidroth has six doubles, two home runs and 31 walks while batting .247.
Lenyn Sosa has 14 doubles, a triple, seven home runs and seven walks while hitting .272.