Guardians vs. Angels Prediction, Odds, Picks - April 6

Steven Kwan and the Cleveland Guardians will meet Jorge Soler and the Los Angeles Angels on Sunday at Angel Stadium, at 4:07 p.m. ET. The favored Guardians have -152 moneyline odds to win against the underdog Angels, who are listed at +127. Cleveland is favored on the run line (-1.5). The game's over/under is listed at 8.5 runs.

Take a look at everything you need from a betting perspective on the Guardians-Angels game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Angels Game Information & Odds

• When: Sunday, April 6, 2025 at 4:07 p.m. ET
• Where: Angel Stadium in Anaheim, California
• How to watch on TV: FDSW and CLEG

Guardians vs. Angels Prediction

• Score Prediction: Angels 6, Guardians 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Guardians 58%, Angels 42%

Guardians vs. Angels Betting Insights

• The Guardians have split the two games they've played as favorites this season.
• Cleveland has played as favorites of -152 or more once this season and lost that game.
• The sportsbooks' moneyline implies a 60.3% chance of a victory for the Guardians.
• The Angels have been underdogs in five games this season and have come away with the win three times (60%) in those contests.
• Los Angeles has played as an underdog of +127 or more just one time this year and came away with a win in that game.
• The moneyline set for this matchup implies the Angels have a 44.1% chance of walking away with the win.

Guardians Player Insights

• Jose Ramirez has put up a team-best four home runs.
• Among all batters in the majors, Ramirez's home run total ranks him fourth, and his RBI tally ranks him 38th.
• Kyle Manzardo has capitalized on opportunities as he leads his team with eight runs batted in.
• Manzardo ranks 37th in home runs and 14th in RBI among all MLB batters this year.
• Manzardo heads into this game looking for his third game in a row with a hit. In his last five games he is batting .125 with a walk and two RBI.
• Kwan has a team-best batting average of .367.
• Kwan is on a four-game hitting streak entering this contest. During his last five outings he is hitting .278 with two walks.
• Carlos Santana is hitting .290 with two doubles, a home run and three walks.
• Santana has recorded at least one hit in three straight games. In his last five games he is batting .368 with a double, a home run, two walks and two RBI.

Guardians Team Props

Angels Player Insights

• Mike Trout has put up a team-leading eight runs batted in.
• Among all hitters in the majors, Trout is 14th in homers and 14th in RBI.
• Trout has collected a hit in four straight games. In his last five games he is batting .211 with a double, three home runs, three walks and eight RBI.
• Logan O'Hoppe's four home runs, eight RBI and .320 batting average are all tops in the lineup.
• Among all MLB batters, O'Hoppe is fourth in homers and 14th in RBI.
• Kyren Paris is hitting .429 with a triple, a home run and three walks.
• Nolan Schanuel has a double, a triple and two walks while batting .290.

Angels Team Props

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Los Angeles Angels

Cleveland Guardians