Giants vs. Red Sox Prediction, Odds, Picks - June 22

Lucas Giolito gets the nod for the Boston Red Sox on Sunday at Oracle Park against Jung Hoo Lee and the San Francisco Giants. First pitch is at 4:05 p.m. ET for the final game of a three-game series. The Red Sox are listed as +139 moneyline underdogs for this matchup with the favored Giants (-165). San Francisco is a 1.5-run favorite (at +136 odds). The over/under is 7.5 runs for the contest.

Here's everything you need from a betting perspective on the Giants-Red Sox game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Red Sox vs. Giants Highlights | MLB on FOX

Check out the best highlights between the Boston Red Sox and San Francisco Giants.

Giants vs. Red Sox Game Information & Odds

• When: Sunday, June 22, 2025 at 4:05 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: NBCS-BA and NESN

Giants vs. Red Sox Prediction

• Score Prediction: Giants 4, Red Sox 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Giants 54%, Red Sox 46%

Giants vs. Red Sox Betting Insights

• This season, the Giants have won 28 out of the 48 games, or 58.3%, in which they've been favored.
• San Francisco is 8-4 this season when entering a game favored by -165 or more on the moneyline.
• The bookmakers' moneyline implies a 62.3% chance of a victory for the Giants.
• The Red Sox have been chosen as underdogs in 29 games this year and have walked away with the win 14 times (48.3%) in those games.
• This year, Boston has won five of eight games when listed as at least +139 or worse on the moneyline.
• The moneyline set for this matchup implies the Red Sox have a 41.8% chance of walking away with the win.

Giants Recent Betting Performance

• The Giants went 3-4 across the seven games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Giants and their opponents combined to go over the run total five times.
• The Giants have put together a 3-7-0 record against the spread over their past 10 games.

Giants Recent Stats

Giants Player Insights

• Rafael Devers has put up a team-best 16 home runs and 61 runs batted in.
• In all of the majors, Devers is 15th in home runs and fourth in RBI.
• Lee is batting .255 with 17 doubles, five triples, six home runs and 26 walks.
• Lee ranks 163rd in home runs and 87th in RBI among all hitters in MLB.
• Heliot Ramos paces the Giants with a team-high batting average of .282.
• Ramos is on a two-game hitting streak entering this contest. During his last five outings he is hitting .222 with two home runs, two walks and three RBIs.
• Wilmer Flores is hitting .255 with seven doubles, 11 home runs and 23 walks.
• Flores has recorded at least one hit in two games in a row. In his last five games he is hitting .154 with a double, a walk and three RBIs.

Giants Team Props

Red Sox Recent Betting Performance

• In six games over the last 10 matchups when set as underdogs by bookmakers, the Red Sox had a record of 4-2.
• In their last 10 games with a total, the Red Sox and their opponents have combined to hit the over two times.
• The Red Sox have a record of 7-3-0 ATS over their last 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Jarren Duran has a team-leading batting average of .257 and paces the Red Sox in runs batted in with a mark of 38.
• Duran is 186th in home runs and 62nd in RBI among all hitters in MLB.
• Wilyer Abreu's 13 home runs pace his team.
• Abreu is 36th among all hitters in the majors in home runs, and 87th in RBI.
• Ceddanne Rafaela has 12 doubles, two triples, seven home runs and 14 walks while batting .251.
• Carlos Narvaez is batting .270 with 15 doubles, six home runs and 26 walks.

Red Sox Team Props

Red Sox vs. Giants Highlights | MLB on FOX

Check out the best highlights between the Boston Red Sox and San Francisco Giants.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

San Francisco Giants

Boston Red Sox