Giants vs. Padres Prediction, Odds, Picks - August 12

Rafael Devers and the San Francisco Giants will try to defeat Manny Machado and the San Diego Padres at Oracle Park on Tuesday at 9:45 p.m. ET. Oddsmakers list the Giants as -119 moneyline favorites, while giving the underdog Padres -101 moneyline odds to win. San Francisco is favored on the run line (-1.5). The matchup's total is set at 7.5 runs.

Take a look at everything you need to know from a betting perspective on the Giants-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Giants vs. Padres Game Information & Odds

• When: Tuesday, August 12, 2025 at 9:45 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: NBCS-BA and SDPA

Giants vs. Padres Prediction

• Score Prediction: Giants 4, Padres 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Giants 52%, Padres 48%

Giants vs. Padres Betting Insights

• This season, the Giants have won 37 out of the 73 games, or 50.7%, in which they've been favored.
• San Francisco has entered 68 games this season favored by -119 or more and is 35-33 in those contests.
• The moneyline for this contest implies a 54.3% chance of a victory for the Giants.
• The Padres have won in 28, or 51.9%, of the 54 contests they have been named as odds-on underdogs this year.
• This season, San Diego has been victorious 26 times in 50 chances when named as an underdog of at least -101 or worse on the moneyline.
• The moneyline set for this matchup implies the Padres have a 50.2% chance of walking away with the win.

Giants Recent Betting Performance

• The Giants went 3-4 across the seven games they were a moneyline favorite in their last 10 matchups.
• In their last 10 outings (all 10 of them had set totals), the Giants and their opponents combined to hit the over four times.
• The Giants are 5-5-0 against the spread over their past 10 games.

Giants Recent Stats

Giants Player Insights

• Devers has gone yard 23 times in the 2025 campaign while driving in 81 runs, both totals that lead the Giants.
• Of all hitters in the majors, Devers is 21st in homers and ninth in RBI.
• Jung Hoo Lee has 27 doubles, nine triples, six home runs and 38 walks while hitting .256.
• Including all MLB hitters, Lee ranks 239th in home runs and 118th in RBI.
• Willy Adames has 18 doubles, two triples, 18 home runs and 55 walks while batting .227.
• Heliot Ramos has a club-best .271 batting average.

Giants Team Props

Padres Recent Betting Performance

• Over the past 10 games, the Padres have been underdogs just once and won that contest.
• In their last 10 games with a total, the Padres and their opponents are 6-4-0 when it comes to hitting the over.
• The Padres have five wins against the spread in their last 10 chances.

Padres Recent Stats

Padres Player Insights

• Machado paces the Padres with 20 home runs and 72 runs batted in, while recording a team-high batting average of .297.
• In all of the big leagues, Machado is 39th in homers and 19th in RBI.
• Fernando Tatis Jr. is hitting .264 with 21 doubles, two triples, 17 home runs and 66 walks.
• Tatis ranks 63rd in homers and 118th in RBI among all hitters in the majors.
• Luis Arraez is batting .292 with 23 doubles, four triples, six home runs and 24 walks.
• Xander Bogaerts is hitting .268 with 25 doubles, 10 home runs and 46 walks.

Padres Team Props

Shohei Ohtani, Aaron Judge Headline 2025 MLB All-Star Game Starters | MLB on FOX

Shohei Ohtani, Aaron Judge, and other superstars headlined the 2025 MLB All-Star Game starting lineup.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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