Dodgers vs. Guardians Prediction, Odds, Picks - May 26

Gavin Williams gets the nod on the mound for the Cleveland Guardians against the Los Angeles Dodgers and Will Smith on Monday at 6:10 p.m. ET. Bookmakers list the Dodgers as -180 moneyline favorites, while giving the underdog Guardians +150 moneyline odds to win. Los Angeles is a 1.5-run favorite (at -103 odds). The total for the matchup has been set at 7.5 runs.

Here's everything you need to know from a betting perspective on the Dodgers-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Tigers Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Detroit Tigers.

Dodgers vs. Guardians Game Information & Odds

• When: Monday, May 26, 2025 at 6:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and SportsNet LA

Dodgers vs. Guardians Prediction

• Score Prediction: Dodgers 6, Guardians 5
• Total Prediction: Over 7.5 runs
• Win Probabilities: Dodgers 50%, Guardians 50%

Dodgers vs. Guardians Betting Insights

• The Dodgers have won 28, or 63.6%, of the 44 games they've played as favorites this season.
• Los Angeles has a record of 20-10 in games when sportsbooks favor them by at least -180 on the moneyline.
• The moneyline for this contest implies a 64.3% chance of a victory for the Dodgers.
• The Guardians have been victorious in 16, or 51.6%, of the 31 contests they have been chosen as underdogs in this season.
• Cleveland has been listed as an underdog of +150 or more on two occasions this season and lost both games.
• Sportsbooks have implied with the moneyline set for this matchup that the Guardians have a 40% chance of pulling out a win.

Dodgers Recent Betting Performance

• The Dodgers have a 3-4 record over the seven games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 outings (all had set totals), the Dodgers combined with their opponents to hit the over on the total five times.
• The Dodgers' ATS record is 3-7-0 over their past 10 games.

Dodgers Recent Stats

Dodgers Player Insights

• Shohei Ohtani's 18 homers in 2025 are the most on the Dodgers. He's also driven in 32 runs while hitting .295.
• Ohtani ranks first in homers and 24th in RBI among all hitters in MLB.
• Mookie Betts is batting .259 with five doubles, a triple, eight home runs and 24 walks.
• Betts ranks 53rd in homers and 35th in RBI on the year.
• Betts has two straight games with at least one hit. During his last five outings he is hitting .227 with a walk.
• Freddie Freeman leads the Dodgers with a team-high batting average of .357.
• Teoscar Hernandez has made the most of his opportunities as he paces his team with 41 runs batted in.
• Hernandez has recorded at least one hit in four games in a row. During his last five outings he is batting .313 with three doubles, a home run, a walk and six RBIs.

Dodgers Team Props

Guardians Recent Betting Performance

• In six games as underdogs over the last 10 matchups, the Guardians have a record of 4-2.
• In their last 10 games with a total, the Guardians and their opponents have combined to hit the over two times.
• The Guardians are 5-5-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez has 10 doubles, a triple, nine home runs and 17 walks while hitting .309.
• Ramirez is 39th in home runs and 72nd in RBI among all hitters in MLB.
• Ramirez carries an 18-game hitting streak into this matchup. During his last 10 games he is hitting .357 with two doubles, a triple, two home runs, two walks and seven RBIs.
• Steven Kwan's .320 batting average leads his team.
• Kwan is 154th among all batters in the majors in homers, and 146th in RBI.
• Carlos Santana paces the Guardians with 27 runs batted in.
• Kyle Manzardo paces the Guardians with 10 home runs and runs batted in, driving in 27.

Guardians Team Props

Guardians vs. Tigers Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Detroit Tigers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

Los Angeles Dodgers