Dodgers vs. Giants Prediction, Odds, Picks - September 19

The Los Angeles Dodgers and Shohei Ohtani will hit the field against the San Francisco Giants and Wilmer Flores on Friday at 10:10 p.m. ET, in the second game of a four-game series at Dodger Stadium. Bookmakers list the Dodgers as -186 favorites on the moneyline, while giving the underdog Giants +154 moneyline odds. Los Angeles is a 1.5-run favorite (at +114 odds). The over/under is 9 runs for the matchup (with -103 odds to hit the over and -117 odds on the under).

Check out everything you need to know from a betting perspective on the Dodgers-Giants game, regarding the run line, moneyline and total, plus expert picks.

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Dodgers vs. Giants Game Information & Odds

• When: Friday, September 19, 2025 at 10:10 p.m. ET
• Where: Dodger Stadium in Los Angeles, California
• How to watch on TV: Apple TV+

Dodgers vs. Giants Prediction

• Score Prediction: Dodgers 5, Giants 4
• Total Prediction: Under 9 runs
• Win Probabilities: Dodgers 55%, Giants 45%

Dodgers vs. Giants Betting Insights

• This season, the Dodgers have won 77 out of the 135 games, or 57%, in which they've been favored.
• Los Angeles has entered 59 games this season favored by -186 or more and is 38-21 in those contests.
• The moneyline for this contest implies a 65% chance of a victory for the Dodgers.
• The Giants have come away with 30 wins in the 65 contests they have been listed as the underdogs in this season.
• San Francisco has a win-loss record of 1-5 when favored by +154 or worse by oddsmakers this year.
• Oddsmakers have implied with the moneyline set for this matchup that the Giants have a 39.4% chance of pulling out a win.

Dodgers Recent Betting Performance

• The Dodgers have a 6-3 record from the nine games they were moneyline favorites over their last 10 matchups.
• In their last 10 outings -- all had a set run total -- the Dodgers and their opponents combined to go over the total five times.
• The Dodgers' ATS record is 7-3-0 over their past 10 games.

Dodgers Recent Stats

Dodgers Player Insights

• Ohtani has racked up a team-high 51 home runs and 95 runs batted in.
• Ohtani ranks third in homers and 15th in RBI among all batters in baseball.
• Ohtani brings a hitting streak of six games into this game. In his last 10 games he is batting .342 with four doubles, three home runs, nine walks and five RBIs.
• Mookie Betts is hitting .260 with 22 doubles, two triples, 19 home runs and 58 walks.
• Betts ranks 81st in homers and 48th in RBI among all hitters in MLB.
• Freddie Freeman leads the Dodgers with a team-best batting average of .295.
• Freeman will look to build on his two-game hitting in this game. During his last five outings he is batting .333 with a double, a home run, two walks and three RBIs.
• Andy Pages has 25 doubles, a triple, 25 home runs and 28 walks while hitting .277.

Dodgers Team Props

Giants Recent Betting Performance

• In six games over the last 10 matchups when set as underdogs by sportsbooks, the Giants had a record of 2-4.
• In their last 10 games with a total, the Giants and their opponents are 5-4-1 when it comes to hitting the over.
• The Giants have a record of 6-4-0 ATS over their last 10 games.

Giants Recent Stats

Giants Player Insights

• Rafael Devers has managed a team-leading 31 home runs and has driven in 104 runs.
• Devers' home run total puts him 14th in MLB, and he is seventh in RBI.
• Jung Hoo Lee has a club-leading .261 batting average.
• Among all MLB hitters, Lee ranks 242nd in home runs and 146th in RBI.
• Willy Adames has 20 doubles, two triples, 28 home runs and 75 walks while hitting .226.
• Heliot Ramos is hitting .257 with 24 doubles, a triple, 17 home runs and 51 walks.

Giants Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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