Diamondbacks vs. Giants Prediction, Odds, Picks - September 16

Jung Hoo Lee and Gabriel Moreno will take the field when the San Francisco Giants and Arizona Diamondbacks meet on Tuesday at Chase Field. Oddsmakers list the Diamondbacks as -131 favorites on the moneyline, while giving the underdog Giants +110 moneyline odds to win. Arizona is the run-line favorite (-1.5). The matchup's over/under is set at 9 runs.

Take a look at everything you need from a betting perspective on the Diamondbacks-Giants game, regarding the run line, moneyline and total, plus expert picks.

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Check out the best highlights between the St. Louis Cardinals and San Francisco Giants.

Diamondbacks vs. Giants Game Information & Odds

• When: Tuesday, September 16, 2025 at 9:40 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: ARID and NBCS-BA

Diamondbacks vs. Giants Prediction

• Score Prediction: Diamondbacks 6, Giants 5
• Total Prediction: Over 9 runs
• Win Probabilities: Diamondbacks 53%, Giants 47%

Diamondbacks vs. Giants Betting Insights

• The Diamondbacks have been favorites in 85 games this season and won 44 (51.8%) of those contests.
• Arizona is 27-25 this season when entering a game favored by -131 or more on the moneyline.
• The implied probability of a win from the Diamondbacks, based on the moneyline, is 56.7%.
• The Giants have been underdogs in 62 games this season and have come away with the win 29 times (46.8%) in those contests.
• This season, San Francisco has come away with a win 17 times in 39 chances when named as an underdog of at least +110 or worse on the moneyline.
• The Giants have an implied victory probability of 47.6% according to the moneyline set for this matchup.

Diamondbacks Recent Betting Performance

• In the last 10 games, the Diamondbacks have been listed as the moneyline favorite by bookmakers only two times, and they split those games.
• In their last 10 matchups (all 10 of them had set totals), the Diamondbacks and their opponents combined to go over the run total six times.
• The Diamondbacks' ATS record is 7-3-0 over their past 10 games.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Geraldo Perdomo is the Diamondbacks best hitter, putting together an average of .290 while also being the team's top run producer, collecting 97 RBI and crushing 19 long balls.
• Among all batters in baseball, Perdomo ranks 80th in homers and 12th in RBI.
• Perdomo carries a six-game hitting streak into this matchup. During his last 10 games he is hitting .400 with a double, a triple, three home runs, eight walks and nine RBIs.
• Corbin Carroll has put his power on display as he paces his team with 30 home runs.
• Carroll ranks 15th in homers and 50th in RBI among all MLB hitters this year.
• Carroll has two games in a row with at least one hit. During his last five outings he is hitting .235 with a double, seven walks and two RBIs.
• Ketel Marte has 23 doubles, 25 home runs and 63 walks while hitting .277.
• Moreno is hitting .289 with 11 doubles, a triple, nine home runs and 21 walks.

Diamondbacks Team Props

Giants Recent Betting Performance

• In five games over the last 10 matchups when set as underdogs by oddsmakers, the Giants had a record of 2-3.
• In their last 10 games with a total, the Giants and their opponents have combined to hit the over five times.
• The Giants have five wins against the spread in their last 10 chances.

Giants Recent Stats

Giants Player Insights

• Rafael Devers leads the Giants with 31 long balls and runs batted in, driving in 102.
• Among all hitters in the big leagues, Devers ranks 12th in homers and eighth in RBI.
• Lee is batting .264 to lead the lineup.
• Lee ranks 234th overall in homers and 143rd in RBI this season.
• Willy Adames is batting .230 with 20 doubles, two triples, 28 home runs and 71 walks.
• Matt Chapman is batting .239 with 20 doubles, two triples, 21 home runs and 66 walks.

Giants Team Props

Giants vs. Cardinals Highlights | MLB on FOX

Check out the best highlights between the St. Louis Cardinals and San Francisco Giants.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Arizona Diamondbacks

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