Diamondbacks vs. Giants Prediction, Odds, Picks - September 15

Jung Hoo Lee and the San Francisco Giants will hit the field on Monday at Chase Field against Zac Gallen, who is projected to start for the Arizona Diamondbacks. First pitch is set for 9:40 p.m. ET for the first game of a three-game series. The favored Diamondbacks have -131 moneyline odds to win against the underdog Giants, who are listed at +110. Arizona is the favorite on the run line (-1.5). The over/under for the game is listed at 9 runs.

Check out everything you need to know from a betting perspective on the Diamondbacks-Giants game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Diamondback vs. Brewers Highlights | MLB on FOX

Check out the best moments between the Arizona Diamondbacks and the Milwaukee Brewers.

Diamondbacks vs. Giants Game Information & Odds

• When: Monday, September 15, 2025 at 9:40 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: ARID and NBCS-BA

Diamondbacks vs. Giants Prediction

• Score Prediction: Diamondbacks 6, Giants 5
• Total Prediction: Over 9 runs
• Win Probabilities: Diamondbacks 52%, Giants 48%

Diamondbacks vs. Giants Betting Insights

• This season, the Diamondbacks have been favored 84 times and won 43, or 51.2%, of those games.
• Arizona has entered 51 games this season favored by -131 or more and is 26-25 in those contests.
• Bookmakers have implied with the moneyline set for this matchup that the Diamondbacks have a 56.7% chance to win.
• The Giants have come away with 29 wins in the 61 contests they have been listed as the underdogs in this season.
• This year, San Francisco has won 17 of 39 games when listed as at least +110 or worse on the moneyline.
• The moneyline set for this matchup implies the Giants have a 47.6% chance of coming away with a victory in the contest.

Diamondbacks Recent Betting Performance

• The Diamondbacks were listed as the moneyline favorite by oddsmakers only twice in the last 10 games, and split those matchups.
• Over their last 10 outings (all 10 of them had set totals), the Diamondbacks and their opponents combined to go over the run total six times.
• The Diamondbacks' ATS record is 7-3-0 over their past 10 games.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Geraldo Perdomo has racked up a team-high batting average of .286 and paces the Diamondbacks in runs batted in (95).
• Among all hitters in the majors, Perdomo ranks 80th in homers and 13th in RBI.
• Perdomo has collected a hit in five games in a row. In his last five games he is hitting .438 with two home runs, five walks and four RBIs.
• Corbin Carroll has shown his power as he leads his team with 30 home runs.
• Carroll ranks 15th in home runs and 49th in RBI among all major league hitters this year.
• Ketel Marte is hitting .279 with 23 doubles, 25 home runs and 63 walks.
• Marte has at least one base hit in two straight games. During his last five outings he is hitting .217 with a double and an RBI.
• Gabriel Moreno has 11 doubles, a triple, nine home runs and 20 walks while batting .292.
• Moreno takes a five-game streak with at least one hit into this one. In his last five games he is hitting .500 with a double, two home runs, three walks and six RBIs.

Diamondbacks Team Props

Giants Recent Betting Performance

• In four games as underdogs over the last 10 matchups, the Giants have a record of 2-2.
• The Giants and their opponents have combined to hit the over six times in their last 10 games with a total.
• The Giants have six wins against the spread in their last 10 chances.

Giants Recent Stats

Giants Player Insights

• Rafael Devers has managed a team-high 31 home runs and has driven in 102 runs.
• Among all hitters in the majors, Devers is 12th in homers and eighth in RBI.
• Lee's .266 batting average is a team-high mark.
• Lee is 234th in homers and 143rd in RBI among all major league hitters this year.
• Willy Adames has 20 doubles, two triples, 28 home runs and 71 walks while batting .232.
• Matt Chapman is batting .241 with 20 doubles, two triples, 21 home runs and 65 walks.

Giants Team Props

Diamondback vs. Brewers Highlights | MLB on FOX

Check out the best moments between the Arizona Diamondbacks and the Milwaukee Brewers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Arizona Diamondbacks

San Francisco Giants