Cubs vs. Reds Prediction, Odds, Picks - May 25

Will Benson and the Cincinnati Reds take the field on Sunday at Great American Ball Park against Ben Brown, who will start for the Chicago Cubs. First pitch is set for 1:40 p.m. ET. Oddsmakers list the Cubs as -128 favorites on the moneyline, while giving the underdog Reds +109 moneyline odds to win. Chicago is a 1.5-run favorite (at +123 odds). The matchup's total is listed at 9 runs.

Check out everything you need to know from a betting perspective on the Cubs-Reds game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Reds Highlights | MLB on FOX

Check out the best highlights between the Chicago Cubs and the Cincinnati Reds.

Cubs vs. Reds Game Information & Odds

• When: Sunday, May 25, 2025 at 1:40 p.m. ET
• Where: Great American Ball Park in Cincinnati, Ohio
• How to watch on TV: MLB Network, FDSOH, and MARQ

Cubs vs. Reds Prediction

• Score Prediction: Cubs 5, Reds 4
• Total Prediction: Under 9 runs
• Win Probabilities: Cubs 52%, Reds 48%

Cubs vs. Reds Betting Insights

• The Cubs have entered the game as favorites 33 times this season and won 22, or 66.7%, of those games.
• Chicago has entered 25 games this season favored by -128 or more and is 17-8 in those contests.
• Sportsbooks have implied with the moneyline set for this matchup that the Cubs have a 56.1% chance to win.
• The Reds have been victorious in 13, or 48.1%, of the 27 contests they have been chosen as underdogs in this season.
• This season, Cincinnati has come away with a win four times in 13 chances when named as an underdog of at least +109 or worse on the moneyline.
• The moneyline set for this matchup implies the Reds have a 47.8% chance of coming away with a victory in the contest.

Cubs Recent Betting Performance

• The Cubs have a 7-3 record across the 10 games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 matchups (all had set totals), the Cubs combined with their opponents to go over the total seven times.
• The Cubs' ATS record is 5-5-0 over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker is hitting .279 with nine doubles, four triples, 12 home runs and 35 walks.
• In all of Major League Baseball, Tucker is 13th in home runs and 11th in RBI.
• Tucker brings a hitting streak of four games into this matchup. During his last five outings he is batting .409 with two home runs, two walks and four RBIs.
• Pete Crow-Armstrong has hit 14 home runs with 46 runs batted in. Both lead his team.
• Among all major league hitters, Crow-Armstrong ranks seventh in home runs and second in RBI.
• Seiya Suzuki has a team-high 46 runs batted in.
• Suzuki is on a five-game hitting streak entering this contest. During his last five outings he is hitting .429 with three doubles, two home runs, three walks and seven RBIs.
• Nico Hoerner has a club-high .295 batting average.
• Hoerner is riding a two-game hitting streak into this one. During his last five outings he is batting .333 with two doubles, a walk and two RBIs.

Cubs Team Props

Reds Recent Betting Performance

• In four games as underdogs over the last 10 matchups, the Reds have a record of 3-1.
• In their last 10 games with a total, the Reds and their opponents are 2-7-1 when it comes to hitting the over.
• Over their last 10 games, the Reds are 6-4-0 against the spread.

Reds Recent Stats

Reds Player Insights

• Elly De La Cruz has put up a team-high nine home runs and has driven in 37 runs.
• In all of MLB, De La Cruz is 36th in homers and 11th in RBI.
• TJ Friedl is batting .280 with nine doubles, two triples, three home runs and 23 walks.
• Among all major league hitters, Friedl is 187th in homers and 130th in RBI.
• Gavin Lux paces the Reds' lineup with a .293 batting average.
• Austin Hays is hitting .317 with six doubles, a triple, six home runs and seven walks.

Reds Team Props

Cubs vs. Reds Highlights | MLB on FOX

Check out the best highlights between the Chicago Cubs and the Cincinnati Reds.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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