Cubs vs. Mets Prediction, Odds, Picks - September 23

The Chicago Cubs versus New York Mets game on Tuesday at 7:40 p.m. ET will feature a pair of hot hitters in Michael Busch and Juan Soto. Bookmakers list the Cubs as -112 moneyline favorites, while giving the underdog Mets -108 moneyline odds to win. New York is the run-line favorite (-1.5). The contest's over/under is listed at 7 runs.

Here's everything you need to know from a betting perspective on the Cubs-Mets game, regarding the run line, moneyline and total, plus expert picks.

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Nationals vs. Mets Highlights | MLB on FOX

Check out the best moments between the Washington Nationals and New York Mets.

Cubs vs. Mets Game Information & Odds

• When: Tuesday, September 23, 2025 at 7:40 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: TBS, MARQ, and SNY

Cubs vs. Mets Prediction

• Score Prediction: Cubs 4, Mets 3
• Total Prediction: Over 7 runs
• Win Probabilities: Cubs 55%, Mets 45%

Cubs vs. Mets Betting Insights

• The Cubs have been favorites in 111 games this season and won 70 (63.1%) of those contests.
• Chicago is 69-40 this season when entering a game favored by -112 or more on the moneyline.
• The bookmakers' moneyline implies a 52.8% chance of a victory for the Cubs.
• The Mets have been chosen as underdogs in 45 games this year and have walked away with the win 18 times (40%) in those games.
• New York has a mark of 16-26 in contests where oddsmakers favor it by -108 or worse on the moneyline.
• The moneyline set for this matchup implies the Mets have a 51.9% chance of walking away with the win.

Cubs Recent Betting Performance

• The Cubs went 4-1 over the five games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 matchups, the Cubs and their opponents combined to hit the over four times (all 10 of the games had set totals).
• The Cubs' ATS record is 7-3-0 over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• The Cubs best hitter so far this season is Nico Hoerner, who's hitting at a team-leading .299 rate along with six homers and 59 RBI.
• Among all MLB batters, Hoerner is eighth in batting average, 41st in on-base percentage, and 108th in slugging.
• Pete Crow-Armstrong has 37 doubles, four triples, 29 home runs and 29 walks while batting .245.
• Crow-Armstrong ranks 29th in home runs and 24th in RBI among all major league hitters this season.
• Ian Happ is hitting .241 with 29 doubles, 23 home runs and 85 walks.
• Seiya Suzuki has made the most of his opportunities as he leads his team with 91 runs batted in.

Cubs Team Props

Mets Recent Betting Performance

• The Mets have been underdogs once in the past 10 games and lost that contest.
• In their last 10 games with a total, the Mets and their opponents have failed to hit the over five times.
• The Mets have a record of 4-6-0 ATS over their last 10 games.

Mets Recent Stats

Mets Player Insights

• Soto paces the Mets with 42 long balls.
• Among all batters in the big leagues, Soto's home run total ranks seventh and his RBI tally ranks 10th.
• Soto brings a hitting streak of six games into this matchup. During his last 10 games he is batting .308 with two doubles, three home runs, five walks and nine RBIs.
• Francisco Lindor is hitting .267 with 34 doubles, 28 home runs and 60 walks.
• Lindor is currently 32nd in homers and 48th in RBI in the big leagues.
• Pete Alonso paces the Mets in runs batted in (122) and has racked up a team-high batting average of .274.
• Brandon Nimmo has 27 doubles, 24 home runs and 49 walks while hitting .260.

Mets Team Props

Nationals vs. Mets Highlights | MLB on FOX

Check out the best moments between the Washington Nationals and New York Mets.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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