Cubs vs. Cardinals Prediction, Odds, Picks - July 4

The Chicago Cubs and Nico Hoerner will hit the field against the St. Louis Cardinals and Masyn Winn on Friday at 2:20 p.m. ET, in the first game of a three-game series at Wrigley Field. Bookmakers list the Cubs as -144 favorites on the moneyline, while giving the underdog Cardinals +121 moneyline odds. Chicago is the favorite on the run line (-1.5). A 9.5-run total has been listed for the contest.

Here's everything you need from a betting perspective on the Cubs-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Cardinals Game Information & Odds

• When: Friday, July 4, 2025 at 2:20 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: Apple TV+

Cubs vs. Cardinals Prediction

• Score Prediction: Cubs 5, Cardinals 4
• Total Prediction: Over 9.5 runs
• Win Probabilities: Cubs 54%, Cardinals 46%

Cubs vs. Cardinals Betting Insights

• The Cubs have entered the game as favorites 60 times this season and won 42, or 70%, of those games.
• Chicago is 28-9 this season when entering a game favored by -144 or more on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Cubs have a 59% chance to win.
• The Cardinals have been chosen as underdogs in 48 games this year and have walked away with the win 25 times (52.1%) in those games.
• This season, St. Louis has been victorious six times in 18 chances when named as an underdog of at least +121 or worse on the moneyline.
• The moneyline set for this matchup implies the Cardinals have a 45.2% chance of coming away with a victory in the contest.

Cubs Recent Betting Performance

• The Cubs were the moneyline favorite for seven of their last 10 games, and they went 5-2 in those matchups.
• Over their last 10 outings (all had set totals), the Cubs combined with their opponents to hit the over on the total five times.
• The Cubs have gone 4-6-0 against the spread over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker's .287 average leads the Cubs this year. His resume also includes 17 homers and driven in 52 RBI.
• Tucker's home runs place him 22nd in the majors, and he ranks 25th in RBI.
• Pete Crow-Armstrong is batting .265 with 20 doubles, four triples, 21 home runs and 16 walks.
• Crow-Armstrong ranks eighth in homers and ninth in RBI among all hitters in MLB.
• Seiya Suzuki has put up a team-best 23 home runs and 73 runs batted in.
• Suzuki has at least one base hit in three games in a row. During his last five outings he is batting .300 with a double, a triple, two home runs, two walks and six RBIs.
• Hoerner is hitting .285 with 17 doubles, a triple, three home runs and 19 walks.

Cubs Team Props

Cardinals Recent Betting Performance

• The Cardinals have played as underdogs in seven of their past 10 games and have gone 3-4 in those contests.
• In their last 10 games with a total, the Cardinals and their opponents have combined to hit the over three times.
• The Cardinals have a record of 6-4-0 ATS over their last 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Brendan Donovan paces the Cardinals with a .293 batting average.
• Donovan's home run total puts him 183rd in the big leagues, and he is 135th in RBI.
• Nolan Arenado has 13 doubles, a triple, 10 home runs and 24 walks while hitting .247.
• Among all major league hitters, Arenado is 96th in home runs and 70th in RBI.
• Willson Contreras has been a significant run producer for the Cardinals with 11 home runs and 51 runs batted in.
• Lars Nootbaar has swatted a team-leading 11 long balls.

Cardinals Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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