Cardinals vs. Reds Prediction, Odds, Picks - September 15

The Cincinnati Reds and Will Benson hit the field in the first game of a three-game series against Willson Contreras and the St. Louis Cardinals, on Monday at Busch Stadium. The favored Cardinals have -113 moneyline odds against the underdog Reds, who are listed at -106. Cincinnati (-1.5) is the favorite on the run line. The total for the contest is set at 8.5 runs.

Take a look at everything you need to know from a betting perspective on the Cardinals-Reds game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Cardinals vs. Brewers Highlights | MLB on FOX

Check out the best moments between the St. Louis Cardinals and the Milwaukee Brewers!

Cardinals vs. Reds Game Information & Odds

• When: Monday, September 15, 2025 at 7:45 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: FDSMW and FDSOH

Cardinals vs. Reds Prediction

• Score Prediction: Cardinals 5, Reds 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Cardinals 51%, Reds 49%

Cardinals vs. Reds Betting Insights

• The Cardinals have entered the game as favorites 66 times this season and won 34, or 51.5%, of those games.
• This season St. Louis has won 31 of its 62 games, or 50%, when favored by at least -113 on the moneyline.
• The moneyline for this contest implies a 53.1% chance of a victory for the Cardinals.
• The Reds have been underdogs in 81 games this season and have come away with the win 39 times (48.1%) in those contests.
• Cincinnati has a mark of 36-40 in contests where sportsbooks favor it by -106 or worse on the moneyline.
• The moneyline set for this matchup implies the Reds have a 51.5% chance of walking away with the win.

Cardinals Recent Betting Performance

• The Cardinals played as the moneyline favorite in three of their last 10 games, and finished 2-1 in those matchups.
• In their last 10 outings -- all had a set run total -- the Cardinals and their opponents combined to hit the over on the total four times.
• The Cardinals' ATS record is 4-6-0 over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Alec Burleson leads the Cardinals with a team-high batting average of .281.
• Burleson is 100th in home runs and 95th in RBI among all hitters in MLB.
• Contreras has hit 20 home runs with 79 runs batted in. Both are team-highs.
• Contreras ranks 70th in home runs and 41st in RBI on the year.
• Contreras carries a two-game streak with at least one hit into this matchup. In his last five games he is batting .389 with a triple, two walks and five RBIs.
• Brendan Donovan is hitting .279 with 25 doubles, 10 home runs and 41 walks.
• Donovan will look to build on his two-game hitting in this game. During his last five outings he is batting .300 with a double, a home run, a walk and three RBIs.
• Lars Nootbaar is batting .240 with 23 doubles, a triple, 13 home runs and 58 walks.

Cardinals Team Props

Reds Recent Betting Performance

• The Reds have played as underdogs in seven of their past 10 games and won three of those contests.
• The Reds and their opponents have combined to hit the over three times in their last 10 games with a total.
• The Reds have a record of 5-5-0 ATS over their last 10 games.

Reds Recent Stats

Reds Player Insights

• Elly De La Cruz paces the Reds in home runs (19), runs batted in (82) and has recorded a team-best batting average of .263.
• Among all hitters in the majors, De La Cruz's home run total is 80th and his RBI tally ranks 31st.
• TJ Friedl is batting .261 with 20 doubles, two triples, 12 home runs and 74 walks.
• Friedl ranks 164th in home runs and 178th in RBI among all major league hitters this year.
• Spencer Steer is hitting .237 with 20 doubles, two triples, 17 home runs and 45 walks.
• Austin Hays is hitting .265 with 15 doubles, five triples, 15 home runs and 29 walks.

Reds Team Props

Cardinals vs. Brewers Highlights | MLB on FOX

Check out the best moments between the St. Louis Cardinals and the Milwaukee Brewers!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

St. Louis Cardinals

Cincinnati Reds