Cardinals vs. Pirates Prediction, Odds, Picks - August 25

The St. Louis Cardinals and Alec Burleson will take on the Pittsburgh Pirates and Jared Triolo on Monday at 7:45 p.m. ET in the first game of a four-game series at Busch Stadium. The Pirates are +113 moneyline underdogs in this matchup against the favored Cardinals (-134). St. Louis is the favorite on the run line (-1.5). The total is 7.5 runs for the contest.

Here is everything you need to know from a betting perspective on the Cardinals-Pirates game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. Pirates Game Information & Odds

• When: Monday, August 25, 2025 at 7:45 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: FDSMW and SportsNet PT

Cardinals vs. Pirates Prediction

• Score Prediction: Cardinals 5, Pirates 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Cardinals 53%, Pirates 47%

Cardinals vs. Pirates Betting Insights

• The Cardinals have won 30, or 51.7%, of the 58 games they've played as favorites this season.
• This season St. Louis has won 15 of its 27 games, or 55.6%, when favored by at least -134 on the moneyline.
• The implied probability of a win from the Cardinals, based on the moneyline, is 57.3%.
• The Pirates have been victorious in 36, or 40.4%, of the 89 contests they have been chosen as underdogs in this season.
• Pittsburgh has a mark of 26-44 in contests where sportsbooks favor it by +113 or worse on the moneyline.
• The moneyline set for this matchup implies the Pirates have a 46.9% chance of walking away with the win.

Cardinals Recent Betting Performance

• The Cardinals have been listed as the moneyline favorite by oddsmakers just twice over the last 10 games, and split those matchups.
• In their last 10 outings, the Cardinals and their opponents combined to go over the run total seven times (all 10 games had set totals).
• The Cardinals' ATS record is 4-6-0 over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Burleson has a team-high batting average of .285.
• Burleson ranks 105th in home runs and 77th in RBI among all hitters in MLB.
• Burleson brings a hitting streak of two games into this game. During his last five outings he is batting .318 with a double, a walk and four RBIs.
• Willson Contreras' 19 home runs and 70 RBI are both team-highs.
• Contreras is 57th in homers and 42nd in RBI on the year.
• Masyn Winn has 26 doubles, nine home runs and 31 walks while batting .258.
• Lars Nootbaar is batting .239 with 20 doubles, 13 home runs and 51 walks.

Cardinals Team Props

Pirates Recent Betting Performance

• The Pirates have played as underdogs in six of their past 10 games and won two of those contests.
• The Pirates and their opponents have combined to hit the over three times in their last 10 games with a total.
• The Pirates have won seven of their last 10 games against the spread.

Pirates Recent Stats

Pirates Player Insights

• Bryan Reynolds has plated a team-leading 63 runs batted in.
• Reynolds' home run total places him 127th in the majors, and he ranks 61st in RBI.
• Andrew McCutchen has 19 doubles, 12 home runs and 53 walks while batting .241.
• McCutchen is currently 141st in home runs and 139th in RBI in the major leagues.
• Isiah Kiner-Falefa has accumulated a team-high batting average of .265.
• Tommy Pham has 14 doubles, a triple, seven home runs and 35 walks while batting .267.

Pirates Team Props

Rockies vs. Pirates Highlights | MLB on FOX

Check out the best highlights between the Colorado Rockies and Pittsburgh Pirates.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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