Brewers vs. Padres Prediction, Odds, Picks - September 24

Chad Patrick and Dylan Cease will each get the start when the Milwaukee Brewers and the San Diego Padres play on Wednesday at PETCO Park, at 4:10 p.m. ET. Oddsmakers list the Brewers as -130 favorites on the moneyline, while giving the underdog Padres +109 moneyline odds. Milwaukee is the favorite on the run line (-1.5 with +131 odds). The over/under is 8 runs for the matchup.

Here is everything you need to know from a betting perspective on the Brewers-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Brewers vs. Cardinals Highlights | MLB on FOX

Check out the best highlights between the Milwaukee Brewers and the St. Louis Cardinals.

Brewers vs. Padres Game Information & Odds

• When: Wednesday, September 24, 2025 at 4:10 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: MLB Network, SDPA, and FDSWI

Brewers vs. Padres Prediction

• Score Prediction: Brewers 5, Padres 4
• Total Prediction: Over 8 runs
• Win Probabilities: Brewers 50%, Padres 50%

Brewers vs. Padres Betting Insights

• This season, the Brewers have been favored 94 times and won 59, or 62.8%, of those games.
• Milwaukee has a record of 45-18 in games when oddsmakers favor them by at least -130 on the moneyline.
• The Brewers have a 56.5% chance to win this game based on the implied probability of the moneyline.
• The Padres have come away with 35 wins in the 69 contests they have been listed as the underdogs in this season.
• This year, San Diego has won 21 of 46 games when listed as at least +109 or worse on the moneyline.
• The Padres have an implied victory probability of 47.8% according to the moneyline set for this matchup.

Brewers Recent Betting Performance

• The Brewers went 5-5 over the 10 games they were moneyline favorites in their last 10 matchups.
• Over their last 10 matchups -- all had a set run total -- the Brewers and their opponents combined to go over the total five times.
• The Brewers have a 3-7-0 record against the spread over their past 10 games.

Brewers Recent Stats

Brewers Player Insights

• William Contreras has 28 doubles, 17 home runs and 84 walks while hitting .262.
• Among all hitters in the majors, Contreras' home run total ranks him 110th, and his RBI tally ranks him 60th.
• Christian Yelich has shown his power as he paces his team with 29 home runs and 102 RBI.
• Yelich ranks 30th in home runs and 11th in RBI among all major league hitters this year.
• Yelich has two straight games with at least one hit. During his last five outings he is hitting .222 with three walks and two RBIs.
• Brice Turang is batting .284 with 26 doubles, two triples, 18 home runs and 63 walks.
• Sal Frelick is batting .291 to pace his team.

Brewers Team Props

Padres Recent Betting Performance

• In five games as underdogs over the last 10 matchups, the Padres have a record of 3-2.
• In their last 10 games with a total, the Padres and their opponents are 6-4-0 when it comes to hitting the over.
• Over their last 10 games, the Padres are 6-4-0 against the spread.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. has 27 doubles, two triples, 23 home runs and 88 walks while hitting .267.
• Tatis ranks 56th in homers and 97th in RBI among all hitters in MLB.
• Tatis takes a hitting streak of five games into this game. During his last five outings he is batting .381 with a home run, two walks and an RBI.
• Manny Machado has hit 26 home runs with 93 RBI, leading the team in both categories.
• Machado ranks 39th overall in homers and 21st in RBI this season.
• Luis Arraez paces the Padres with a team-best batting average of .288.
• Ramon Laureano has 26 doubles, two triples, 24 home runs and 35 walks while hitting .282.

Padres Team Props

Brewers vs. Cardinals Highlights | MLB on FOX

Check out the best highlights between the Milwaukee Brewers and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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