Astros vs. White Sox Prediction, Odds, Picks - May 4

The Houston Astros and Yainer Diaz head into the final of a three-game series against Miguel Vargas and the Chicago White Sox on Sunday at Rate Field. The Astros are the favorite in this one, at -176, while the underdog White Sox have +146 odds to play spoiler. Houston (-1.5) is favored on the run line. The over/under is 8.5 runs for this game (with -101 odds on the over and -120 odds to go under).

Here's everything you need from a betting perspective on the Astros-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. White Sox Highlights | MLB on FOX

Check out the best moments between the Houston Astros and the Chicago White Sox.

Astros vs. White Sox Game Information & Odds

• When: Sunday, May 4, 2025 at 2:10 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and SCHN

Astros vs. White Sox Prediction

• Score Prediction: Astros 6, White Sox 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Astros 52%, White Sox 48%

Astros vs. White Sox Betting Insights

• The Astros have won 12, or 52.2%, of the 23 games they've played as favorites this season.
• Houston has played as favorites of -176 or more twice this season and split those games.
• The sportsbooks' moneyline implies a 63.8% chance of a victory for the Astros.
• The White Sox have been victorious in nine, or 27.3%, of the 33 contests they have been chosen as underdogs in this season.
• This year, Chicago has won five of 21 games when listed as at least +146 or worse on the moneyline.
• The White Sox have an implied victory probability of 40.7% according to the moneyline set for this matchup.

Astros Recent Betting Performance

• The Astros have a 5-4 record from the nine games they were favored on the moneyline over their last 10 matchups.
• Over their last 10 matchups, the Astros and their opponents combined to go over the run total six times (all 10 of the games had set totals).
• The Astros have a 6-4-0 record against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• The Astros leader in both batting average and home runs is Jeremy Pena, who comes into the game hitting .283 and has left the yard four times while driving in 12 runs this season.
• In all of Major League Baseball, Pena ranks 88th in homers and 139th in RBI.
• Pena has collected a hit in seven games in a row. In his last 10 games he is hitting .390 with two doubles, a home run, two walks and five RBI.
• Isaac Paredes has shown his power as he paces his team with four home runs.
• Of all MLB batters, Paredes is 88th in home runs and 96th in RBI.
• Paredes carries a five-game streak with at least one hit into this matchup. During his last five outings he is hitting .278 with a triple, four walks and an RBI.
• Jose Altuve paces the Astros with four home runs.
• Altuve will look to build on his three-game hitting in this matchup. In his last five games he is batting .238 with a double, a home run, three walks and five RBI.
• Jake Meyers is batting .295 with five doubles, a triple, two home runs and six walks.
• Meyers brings a four-game streak with at least one hit into this one. During his last five outings he is hitting .444 with a double, a triple, two home runs, a walk and eight RBI.

Astros Team Props

White Sox Recent Betting Performance

• In 10 games as underdogs over the last 10 matchups, the White Sox have a record of 4-6.
• In their last 10 games with a total, the White Sox and their opponents have failed to hit the over three times.
• The White Sox have won six of their last 10 games against the spread.

White Sox Recent Stats

White Sox Player Insights

• Luis Robert has posted a team-high five home runs and has driven in 14 runs.
• Among all hitters in the big leagues, Robert's home run total is 55th and his RBI tally ranks 96th.
• Vargas is batting .219 with six doubles, two home runs and 14 walks.
• Vargas is 173rd overall in homers and 139th in RBI this season.
• Andrew Benintendi has five home runs, best in the lineup.
• Brooks Baldwin has put up a team-leading 14 runs batted in.

White Sox Team Props

Astros vs. White Sox Highlights | MLB on FOX

Check out the best moments between the Houston Astros and the Chicago White Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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