Astros vs. Reds Prediction, Odds, Picks - May 9

Jake Meyers and the Houston Astros take the field on Friday at Daikin Park against Nicholas Martinez, who is starting for the Cincinnati Reds. First pitch is set for 8:10 p.m. ET for the first game of a three-game series. Bookmakers list the Astros as -141 moneyline favorites, while giving the underdog Reds +119 moneyline odds to win. Houston is the run-line favorite (-1.5). The over/under for the contest is set at 8 runs.

Here's everything you need from a betting perspective on the Astros-Reds game, regarding the run line, moneyline and total, plus expert picks.

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Jeremy Peña smashes a three-run home run, extending the Astros' lead over Brewers

Jeremy Peña smashed a three-run home run, extending the Houston Astros' lead over Milwaukee Brewers.

Astros vs. Reds Game Information & Odds

• When: Friday, May 9, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and FDSOH

Astros vs. Reds Prediction

• Score Prediction: Astros 4, Reds 3
• Total Prediction: Under 8 runs
• Win Probabilities: Astros 56%, Reds 44%

Astros vs. Reds Betting Insights

• The Astros have won 13, or 52%, of the 25 games they've played as favorites this season.
• Houston has a record of 5-6 in games when oddsmakers favor them by at least -141 on the moneyline.
• The moneyline for this contest implies a 58.5% chance of a victory for the Astros.
• The Reds have won in nine, or 45%, of the 20 contests they have been named as odds-on underdogs this year.
• This season, Cincinnati has been victorious three times in eight chances when named as an underdog of at least +119 or longer on the moneyline.
• The Reds have an implied victory probability of 45.7% according to the moneyline set by sportsbooks for this matchup.

Astros Recent Betting Performance

• The Astros have a 5-3 record across the eight games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Astros and their opponents combined to go over the run total eight times.
• The Astros have gone 6-4-0 against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jeremy Pena's five round-trippers in 2025 are the most on the Astros. He's also knocked in 16 runs while hitting .279.
• Pena's home runs put him 66th in the majors, and he ranks 96th in RBI.
• Isaac Paredes is batting .256 with three doubles, a triple, four home runs and 21 walks.
• Paredes ranks 100th in homers in MLB, and 117th in RBI.
• Jose Altuve has four doubles, four home runs and 10 walks while batting .252.
• Meyers is batting .297 to pace his team.
• Meyers has recorded at least one hit in eight straight games. During his last 10 outings he is batting .364 with a double, a triple, two home runs, four walks and eight RBIs.

Astros Team Props

Reds Recent Betting Performance

• In five games as underdogs over the last 10 matchups, the Reds have a record of 2-3.
• In their last 10 games with a total, the Reds and their opponents are 4-6-0 when it comes to hitting the over.
• The Reds have a record of 4-6-0 ATS over their last 10 games.

Reds Recent Stats

Reds Player Insights

• Elly De La Cruz has put up a team-high five home runs and has driven in 25 runs.
• De La Cruz's home run total puts him 66th in the big leagues, and he ranks 16th in RBI.
• TJ Friedl is hitting .272 with six doubles, a triple, three home runs and 15 walks.
• Friedl ranks 141st overall in homers and 96th in RBI this year.
• Gavin Lux leads the Reds' lineup with a .298 batting average.
• Jose Trevino is batting .310 with nine doubles, three home runs and five walks.

Reds Team Props

Jeremy Peña smashes a three-run home run, extending the Astros' lead over Brewers

Jeremy Peña smashed a three-run home run, extending the Houston Astros' lead over Milwaukee Brewers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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