Astros vs. Padres Prediction, Odds, Picks - April 20

The Houston Astros and San Diego Padres will play on Sunday at Daikin Park, at 7:10 p.m. ET, with Jeremy Pena and Fernando Tatis Jr. -- two hot hitters -- expected to produce at the plate. The Astros are favored in this one, at -114, while the underdog Padres have -106 odds to play spoiler. San Diego is the favorite on the run line (-1.5 with +163 odds). The game's total is listed at 7.5 runs.

Check out everything you need to know from a betting perspective on the Astros-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Padres Game Information & Odds

• When: Sunday, April 20, 2025 at 7:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: ESPN

Astros vs. Padres Prediction

• Score Prediction: Padres 5, Astros 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Astros 52%, Padres 48%

Astros vs. Padres Betting Insights

• The Astros have entered the game as favorites 12 times this season and won six, or 50%, of those games.
• Houston has a record of 6-5 in games when sportsbooks favor them by at least -114 on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Astros have a 53.3% chance to win.
• The Padres have been victorious in four of the eight contests they have been chosen as underdogs in this season.
• This season, San Diego has been victorious four times in eight chances when named as an underdog of at least -106 or worse on the moneyline.
• The moneyline set for this matchup implies the Padres have a 51.5% chance of coming away with a victory in the contest.

Astros Recent Betting Performance

• The Astros went 4-3 across the seven games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 outings (all 10 of them had set totals), the Astros and their opponents combined to go over the run total five times.
• The Astros are 6-4-0 against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Pena has launched a team-high three homers.
• Pena is 72nd in homers and 154th in RBI among all hitters in baseball.
• Pena has collected a hit in 10 games in a row. During his last 10 outings he is batting .297 with two doubles, a home run, five walks and five RBI.
• Jose Carlos Altuve's three home runs and .305 batting average both pace his team.
• Altuve ranks 72nd in home runs and 154th in RBI among all batters in the majors.
• Isaac Paredes paces the Astros with three home runs and 11 runs batted in.
• Jake Meyers has three doubles and five walks while batting .291.

Astros Team Props

Padres Recent Betting Performance

• In three games as underdogs over the last 10 matchups, the Padres have a record of 1-2.
• In their last 10 games with a total, the Padres and their opponents are 4-6-0 when it comes to hitting the over.
• The Padres have seven wins against the spread in their last 10 chances.

Padres Recent Stats

Padres Player Insights

• Tatis leads the Padres with seven home runs and 15 runs batted in, while recording a team-best batting average of .351.
• In all of the big leagues, Tatis ranks fourth in home runs and 22nd in RBI.
• Tatis brings a hitting streak of eight games into this matchup. In his last 10 games he is hitting .333 with six home runs, five walks and nine RBI.
• Manny Machado is batting .304 with nine doubles, two home runs and eight walks.
• Machado ranks 115th in home runs and 78th in RBI among all major league batters this year.
• Luis Sangel (Reveron) Arraez has three doubles, three home runs and five walks while batting .287.
• Xander Bogaerts is hitting .254 with seven doubles and 10 walks.

Padres Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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