Wyoming vs. Nevada Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 9:04 a.m. ET

FOX Sports

The Wyoming Cowboys (4-6) host the Nevada Wolf Pack (2-8) on Saturday, November 22, 2025 in a matchup between MWC rivals at Jonah Field at War Memorial Stadium. Nevada is a 6.5-point underdog. A total of 40.5 points has been set for this game.

The Cowboys lost to the Fresno State Bulldogs, 24-3, in their last contest. The Wolf Pack's most recent game was against the San Jose State Spartans, and they won by a score of 55-10.

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Wyoming vs. Nevada Game Information & Odds

When: Saturday, November 22, 2025 at 2 p.m. ET
Location: Jonah Field at War Memorial Stadium in Laramie, Wyoming
TV: MW Network
Live Box Score on FOX Sports

Wyoming vs Nevada Betting Information updated as of November 22, 2025, 7:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Wyoming	-6.5 (-112)	-246	+201	40.5	-105	-115

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Wyoming vs. Nevada Prediction

Pick ATS: Wyoming (-6.5)
Pick OU: Over (40.5)
Prediction: Wyoming 27, Nevada 16

Predictions are made by the Data Skrive betting model.

Learn more about the Wyoming Cowboys vs. the Nevada Wolf Pack game on FOX Sports!

Wyoming vs. Nevada Betting Insights

Based on the spread and over/under, the implied score for the matchup is Cowboys 24, Wolf Pack 17.
The Cowboys have a 71.1% chance to win this contest based on the moneyline's implied probability. The Wolf Pack have a 33.2% implied probability.
Wyoming has covered five times in 10 games with a spread this season.
Nevada has compiled a 4-5-1 ATS record so far this year.

Wyoming vs. Nevada: 2025 Stats Comparison

	Wyoming	Nevada
Off. Points per Game (Rank)	17.8 (128)	18.1 (125)
Def. Points per Game (Rank)	20.6 (32)	28.1 (91)
Turnovers Allowed (Rank)	17 (111)	24 (136)
Turnovers Forced (Rank)	13 (57)	13 (57)

Wyoming 2025 Key Players

Name	Position	Stats
Kaden Anderson	QB	1,791 YDS (56.2%) / 11 TD / 10 INT
Samuel Harris	RB	546 YDS / 1 TD / 54.6 YPG / 5.6 YPC 15 REC / 182 REC YDS / 0 REC TD / 20.2 REC YPG
Chris Durr Jr.	WR	40 REC / 479 YDS / 4 TD / 47.9 YPG
Sam Scott	RB	352 YDS / 2 TD / 35.2 YPG / 4.7 YPC 8 REC / 99 REC YDS / 1 REC TD / 11 REC YPG
Evan Eller	LB	43 TKL / 3 TFL / 2 SACK / 1 INT
Brayden Johnson	LB	43 TKL / 3 TFL / 1 SACK / 2 INT
Andrew Johnson	DB	36 TKL / 2 TFL / 1 SACK
Desman Hearns	DB	25 TKL / 0 TFL / 2 INT / 2 PD

Nevada 2025 Key Players

Name	Position	Stats
Caleb Ramseur	RB	500 YDS / 3 TD / 50 YPG / 4.8 YPC 14 REC / 162 REC YDS / 3 REC TD / 23.1 REC YPG
Chubba Purdy	QB	577 YDS (51.8%) / 3 TD / 8 INT 392 RUSH YDS / 3 RUSH TD / 43.6 RUSH YPG
Carter Jones	QB	839 YDS (63.4%) / 5 TD / 8 INT
Jett Carpenter	TE	28 REC / 306 YDS / 1 TD / 30.6 YPG
Dylan Labarbera	DL	56 TKL / 12 TFL / 7 SACK
Murvin Kenion III	DB	41 TKL / 2 TFL / 0.5 SACK / 3 INT
Jonathan Maldonado	DL	26 TKL / 4 TFL / 4.5 SACK / 1 INT
Stone Combs	LB	43 TKL / 1 TFL / 0.5 SACK