USC vs. Northwestern Prediction, Odds, Picks - November 7, 2025

Updated Nov. 7, 2025 9:06 p.m. ET

Data Skrive

The No. 20 USC Trojans (6-2) and the eighth-ranked scoring offense will hit the field against the Northwestern Wildcats (5-3) and the 13th-ranked scoring defense on Friday, November 7, 2025. The Trojans are heavily favored by 14.5 points in the game. The over/under is set at 53.5.

Against the Nebraska Cornhuskers in their last game, the Trojans won 21-17. Against the Nebraska Cornhuskers in their most recent game, the Wildcats lost 28-21.

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USC vs. Northwestern Game Information & Odds

When: Friday, November 7, 2025 at 9 p.m. ET
Location: Los Angeles Memorial Coliseum in Los Angeles, California
TV: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

USC vs Northwestern Betting Information updated as of November 7, 2025, 8:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
USC	-14.5 (-108)	-645	+467	53.5	-115	-105

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USC vs. Northwestern Prediction

Pick ATS: USC (-14.5)
Pick OU: Under (53.5)
Prediction: USC 33, Northwestern 17

Predictions are made by the Data Skrive betting model.

Learn more about the USC Trojans vs. the Northwestern Wildcats game on FOX Sports!

USC vs. Northwestern Betting Insights

Based on the spread and over/under, the implied score for the tilt is Trojans 34, Wildcats 20.
The Trojans have an 86.6% chance to claim victory in this contest per the moneyline's implied probability. The Wildcats hold a 17.6% implied probability.
USC has compiled a 4-4-0 ATS record so far this year.
Northwestern has put together a 5-2-1 ATS record so far this season.

USC vs. Northwestern: 2025 Stats Comparison

	USC	Northwestern
Off. Points per Game (Rank)	39.8 (18)	22.5 (108)
Def. Points per Game (Rank)	22.4 (39)	16.8 (12)
Turnovers Allowed (Rank)	11 (72)	13 (99)
Turnovers Forced (Rank)	13 (34)	9 (86)

USC 2025 Key Players

Name	Position	Stats
Jayden Maiava	QB	2,315 YDS (65.3%) / 15 TD / 5 INT 103 RUSH YDS / 5 RUSH TD / 12.9 RUSH YPG
Makai Lemon	WR	50 REC / 776 YDS / 6 TD / 97 YPG
Waymond Jordan	RB	576 YDS / 5 TD / 96 YPG / 6.5 YPC
King Miller	RB	509 YDS / 4 TD / 84.8 YPG / 7.8 YPC 6 REC / 41 REC YDS / 0 REC TD / 10.3 REC YPG
Eric Gentry	LB	38 TKL / 4 TFL / 3 SACK
Bishop Fitzgerald	DB	29 TKL / 2 TFL / 1 SACK / 5 INT
Anthony Lucas	DL	21 TKL / 3 TFL / 3 SACK
Kameryn Fountain	DL	13 TKL / 5 TFL / 3.5 SACK

Northwestern 2025 Key Players

Name	Position	Stats
Caleb Komolafe	RB	608 YDS / 7 TD / 76 YPG / 4.9 YPC
Griffin Wilde	WR	39 REC / 570 YDS / 4 TD / 71.3 YPG
Preston Stone	QB	1,372 YDS (58.3%) / 10 TD / 9 INT
Joseph Himon II	RB	397 YDS / 0 TD / 49.6 YPG / 4.9 YPC 19 REC / 115 REC YDS / 0 REC TD / 14.4 REC YPG
Mac Uihlein	LB	58 TKL / 4 TFL / 4 INT / 4 PD
Robert Fitzgerald	DB	68 TKL / 3 TFL
Aidan Hubbard	DL	22 TKL / 5 TFL / 3.5 SACK
Michael Kilbane	DL	25 TKL / 3 TFL / 2.5 SACK