USC vs. Georgia Southern Prediction, Odds, Picks - September 6, 2025

Updated Sep. 6, 2025 3:04 p.m. ET

FOX Sports

The Georgia Southern Eagles (0-1) are big 28.5-point underdogs on Saturday, September 6, 2025 against the USC Trojans (1-0). The over/under is 61 for this game.

The Trojans beat the Missouri State Bears, 73-13, in their most recent contest. In their last game, the Eagles lost against the Fresno State Bulldogs, 42-14.

Keep up with college football all season on FOX Sports.

Missouri State Bears vs. USC Trojans Highlights | FOX College Football

Check out the best moments between the Missouri State Bears and USC Trojans in Week 1!

USC vs. Georgia Southern Game Information & Odds

When: Saturday, September 6, 2025 at 7:30 p.m. ET
Location: Los Angeles Memorial Coliseum in Los Angeles, California
TV: Fox Sports 1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

USC vs Georgia Southern Betting Information updated as of September 6, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
USC	-28.5 (-118)	-7692	+1920	61	-110	-110

USC vs. Georgia Southern Prediction

Pick ATS: Georgia Southern (+28.5)
Pick OU: Over (61)
Prediction: USC 44, Georgia Southern 27

Predictions are made by the Data Skrive betting model.

Learn more about the USC Trojans vs. the Georgia Southern Eagles game on FOX Sports!

USC vs. Georgia Southern Betting Insights

Per the spread and over/under, the implied score for the matchup is Trojans 45, Eagles 16.
The Trojans have a 98.7% chance to claim victory in this contest based on the moneyline's implied probability. The Eagles have a 5.0% implied probability.
USC has a record of 1-0-0 against the spread this season.
Georgia Southern has put together a 0-1-0 record against the spread this year.

USC vs. Georgia Southern: 2025 Stats Comparison

	USC	Georgia Southern
Off. Points per Game (Rank)	73 (6)	14 (107)
Def. Points per Game (Rank)	13 (50)	42 (118)
Turnovers Allowed (Rank)	1 (55)	1 (55)
Turnovers Forced (Rank)	3 (8)	3 (8)

USC 2025 Key Players

Name	Position	Stats
Jayden Maiava	QB	295 YDS (83.3%) / 2 TD / 0 INT 9 RUSH YDS / 1 RUSH TD / 9 RUSH YPG
Husan Longstreet	QB	69 YDS (100%) / 1 TD / 0 INT 54 RUSH YDS / 2 RUSH TD / 54 RUSH YPG
Eli Sanders	RB	33 YDS / 0 TD / 33 YPG / 6.6 YPC 1 REC / 73 REC YDS / 1 REC TD / 73 REC YPG
King Miller	RB	80 YDS / 1 TD / 80 YPG / 20 YPC
Braylan Shelby	DL	2 TKL / 2 TFL / 2 SACK
Jide Abasiri	DL	1 TKL / 1 TFL / 1 SACK
Kameryn Fountain	DL	1 TKL / 1 TFL / 1 SACK
Kennedy Urlacher	DB	1 TKL / 1 TFL / 1 SACK

Georgia Southern 2025 Key Players

Name	Position	Stats
JC French	QB	158 YDS (60.7%) / 2 TD / 1 INT 15 RUSH YDS / 0 RUSH TD / 15 RUSH YPG
Camden Brown	WR	4 REC / 55 YDS / 1 TD / 55 YPG
River Helms	TE	1 REC / 4 YDS / 1 TD / 4 YPG
Josh Dallas	WR	5 REC / 48 YDS / 0 TD / 48 YPG
Brandon Tyson	LB	8 TKL / 0 TFL / 1 INT / 1 PD
Jayden Davis	DB	10 TKL / 0 TFL
Chance Gamble	DB	4 TKL / 0 TFL / 1 INT / 1 PD
Davion Rhodes	DL	3 TKL / 1 TFL