South Carolina vs. Kentucky Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 3:04 p.m. ET

FOX Sports

The South Carolina Gamecocks (2-2) are 5.5-point favorites when they host the Kentucky Wildcats (2-1) in an SEC matchup on Saturday, September 27, 2025 at Williams-Brice Stadium. The total is 47.5 points for this game.

The Gamecocks lost against the Missouri Tigers in their most recent game, 29-20. Against the Eastern Michigan Eagles in their most recent contest, the Wildcats won 48-23.

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South Carolina vs. Kentucky Game Information & Odds

When: Saturday, September 27, 2025 at 7:45 p.m. ET
Location: Williams-Brice Stadium in Columbia, South Carolina
TV: SEC Network
Live Box Score on FOX Sports

South Carolina vs Kentucky Betting Information updated as of September 27, 2025, 12:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
South Carolina	-5.5 (-111)	-221	+181	47.5	-108	-112

South Carolina vs. Kentucky Prediction

Pick ATS: Kentucky (+5.5)
Pick OU: Over (47.5)
Prediction: South Carolina 24, Kentucky 23

Predictions are made by the Data Skrive betting model.

Learn more about the South Carolina Gamecocks vs. the Kentucky Wildcats game on FOX Sports!

South Carolina vs. Kentucky Betting Insights

Per the spread and over/under, the implied score for the game is Gamecocks 26, Wildcats 21.
The Gamecocks have a 68.8% chance to claim victory in this game based on the moneyline's implied probability. The Wildcats have a 35.6% implied probability.
South Carolina has covered twice in four games with a spread this season.
Kentucky has covered once in three chances against the spread this season.

South Carolina vs. Kentucky: Head-to-Head

In their last four head-to-head meetings, South Carolina has taken down Kentucky three times.
In those matchups against Kentucky, the Gamecocks have covered three times while never going over the total.
Kentucky has been outpaced by 32 points in its last four tilts against South Carolina.

South Carolina vs. Kentucky: 2025 Stats Comparison

	South Carolina	Kentucky
Off. Points per Game (Rank)	22.3 (96)	31.7 (88)
Def. Points per Game (Rank)	20.3 (57)	23 (46)
Turnovers Allowed (Rank)	4 (50)	2 (17)
Turnovers Forced (Rank)	5 (50)	4 (75)

South Carolina 2025 Key Players

Name	Position	Stats
LaNorris Sellers	QB	733 YDS (64.4%) / 4 TD / 1 INT 17 RUSH YDS / 1 RUSH TD / 4.3 RUSH YPG
Vandrevius Jacobs	WR	13 REC / 215 YDS / 2 TD / 71.7 YPG
Nyck Harbor	WR	10 REC / 210 YDS / 1 TD / 52.5 YPG
Rahsul Faison	RB	140 YDS / 1 TD / 35 YPG / 4.2 YPC
Dylan Stewart	DL	18 TKL / 5 TFL / 3 SACK
Fred Johnson	LB	18 TKL / 1 TFL / 1 SACK / 1 INT
Vicari Swain	DB	12 TKL / 0 TFL
Justin Okoronkwo	LB	16 TKL / 1 TFL / 1 INT / 1 PD

Kentucky 2025 Key Players

Name	Position	Stats
Seth McGowan	RB	275 YDS / 6 TD / 91.7 YPG / 5.4 YPC
Dante Dowdell	RB	214 YDS / 1 TD / 71.3 YPG / 5.9 YPC
Cutter Boley	QB	278 YDS (54.2%) / 2 TD / 0 INT 38 RUSH YDS / 0 RUSH TD / 19 RUSH YPG
Josh Kattus	TE	8 REC / 112 YDS / 1 TD / 37.3 YPG
Alex Afari	LB	26 TKL / 3 TFL / 1 SACK
Ty Bryant	DB	21 TKL / 0 TFL / 2 INT / 2 PD
Steven Soles Jr.	LB	6 TKL / 0 TFL / 2 SACK
Jonquis Hardaway	DB	15 TKL / 0 TFL / 1 INT / 1 PD