Oregon vs. USC Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 3:04 p.m. ET

FOX Sports

The No. 6 Oregon Ducks (9-1) bring the first-ranked passing defense in college football into a matchup with the No. 16 USC Trojans (8-2), who have the No. 9 passing attack, on Saturday, November 22, 2025. The Ducks are double-digit, 10.5-point favorites. The game has an over/under of 59.5.

The Ducks' most recent game was against the Minnesota Golden Gophers, and they won by a score of 42-13. In their last game, the Trojans won against the Iowa Hawkeyes, 26-21.

Keep up with college football all season on FOX Sports.

Oregon vs. USC Game Information & Odds

When: Saturday, November 22, 2025 at 3:30 p.m. ET
Location: Autzen Stadium in Eugene, Oregon
TV: CBS
Live Box Score on FOX Sports

Oregon vs USC Betting Information updated as of November 22, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oregon	-10.5 (-107)	-420	+326	59.5	-108	-112

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Oregon vs. USC Prediction

Pick ATS: USC (+10.5)
Pick OU: Under (59.5)
Prediction: Oregon 30, USC 25

Predictions are made by the Data Skrive betting model.

Learn more about the Oregon Ducks vs. the USC Trojans game on FOX Sports!

Oregon vs. USC Betting Insights

Per the spread and over/under, the implied score for the game is Ducks 35, Trojans 24.
The Ducks have an 80.8% chance to win this contest based on the moneyline's implied probability. The Trojans hold a 23.5% implied probability.
Oregon has covered five times in 10 chances against the spread this season.
USC has put together a 5-5-0 record against the spread this season.

Oregon vs. USC: 2025 Stats Comparison

	Oregon	USC
Off. Points per Game (Rank)	39 (11)	38.2 (14)
Def. Points per Game (Rank)	13.7 (6)	21.7 (38)
Turnovers Allowed (Rank)	8 (8)	12 (54)
Turnovers Forced (Rank)	13 (57)	16 (32)

Oregon 2025 Key Players

Name	Position	Stats
Dante Moore	QB	2,190 YDS (72.8%) / 21 TD / 5 INT 183 RUSH YDS / 0 RUSH TD / 18.3 RUSH YPG
Jordon Davison	RB	461 YDS / 12 TD / 46.1 YPG / 7.1 YPC
Noah Whittington	RB	623 YDS / 5 TD / 77.9 YPG / 8.2 YPC 11 REC / 48 REC YDS / 1 REC TD / 9.6 REC YPG
Kenyon Sadiq	TE	30 REC / 407 YDS / 6 TD / 45.2 YPG
Teitum Tuioti	LB	47 TKL / 7 TFL / 5.5 SACK
Bryce Boettcher	LB	72 TKL / 1 TFL / 1 SACK / 1 INT
Aaron Flowers	DB	43 TKL / 1 TFL / 1 INT / 1 PD
Jerry Mixon	LB	38 TKL / 1 TFL / 0.5 SACK / 2 INT

USC 2025 Key Players

Name	Position	Stats
Jayden Maiava	QB	2,868 YDS (66.8%) / 18 TD / 6 INT 124 RUSH YDS / 6 RUSH TD / 12.4 RUSH YPG
Makai Lemon	WR	71 REC / 1,090 YDS / 8 TD / 109 YPG
King Miller	RB	719 YDS / 5 TD / 89.9 YPG / 7.3 YPC
Waymond Jordan	RB	576 YDS / 5 TD / 96 YPG / 6.5 YPC
Eric Gentry	LB	41 TKL / 4 TFL / 3 SACK
Bishop Fitzgerald	DB	31 TKL / 2 TFL / 1 SACK / 5 INT
Anthony Lucas	DL	27 TKL / 3 TFL / 3 SACK
Kameryn Fountain	DL	17 TKL / 5 TFL / 3.5 SACK