Northwestern vs. UCLA Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 3:04 p.m. ET

Data Skrive

The Northwestern Wildcats (1-2) host the UCLA Bruins (0-3) on Saturday, September 27, 2025 in a matchup between Big Ten foes at Northwestern Medicine Field at Martin Stadium. UCLA is a 6.5-point underdog. The game has an over/under of 45.5.

Against the Oregon Ducks in their most recent game, the Wildcats lost 34-14. In their most recent contest, the Bruins lost against the New Mexico Lobos, 35-10.

Keep up with college football all season on FOX Sports.

Northwestern vs. UCLA Game Information & Odds

When: Saturday, September 27, 2025 at 3:30 p.m. ET
Location: Northwestern Medicine Field at Martin Stadium in Evanston, Illinois
TV: BTN
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Northwestern vs UCLA Betting Information updated as of September 27, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Northwestern	-6.5 (-108)	-222	+182	45.5	-110	-110

Northwestern vs. UCLA Prediction

Pick ATS: Northwestern (-6.5)
Pick OU: Under (45.5)
Prediction: Northwestern 30, UCLA 13

Predictions are made by the Data Skrive betting model.

Learn more about the Northwestern Wildcats vs. the UCLA Bruins game on FOX Sports!

Northwestern vs. UCLA Betting Insights

Per the spread and over/under, the implied score for the game is Wildcats 26, Bruins 20.
The Wildcats have a 68.9% chance to collect the win in this meeting based on the moneyline's implied probability. The Bruins have a 35.5% implied probability.
Northwestern has covered twice in three matchups with a spread this season.
UCLA has compiled a 0-3-0 record against the spread this season.

Northwestern vs. UCLA: 2025 Stats Comparison

	Northwestern	UCLA
Off. Points per Game (Rank)	19.7 (126)	14.3 (133)
Def. Points per Game (Rank)	21.3 (36)	36 (101)
Turnovers Allowed (Rank)	8 (123)	4 (50)
Turnovers Forced (Rank)	2 (116)	2 (116)

Northwestern 2025 Key Players

Name	Position	Stats
Cam Porter	RB	137 YDS / 1 TD / 68.5 YPG / 7.6 YPC 3 REC / 23 REC YDS / 0 REC TD / 23 REC YPG
Griffin Wilde	WR	15 REC / 213 YDS / 0 TD / 71 YPG
Caleb Komolafe	RB	150 YDS / 1 TD / 50 YPG / 4.2 YPC
Joseph Himon II	RB	137 YDS / 0 TD / 45.7 YPG / 4.9 YPC 7 REC / 59 REC YDS / 0 REC TD / 19.7 REC YPG
Mac Uihlein	LB	20 TKL / 2 TFL / 2 INT / 2 PD
Robert Fitzgerald	DB	26 TKL / 0 TFL
Carmine Bastone	DL	8 TKL / 1 TFL / 1.5 SACK
Aidan Hubbard	DL	9 TKL / 2 TFL / 1 SACK

UCLA 2025 Key Players

Name	Position	Stats
Nico Iamaleava	QB	608 YDS (63.9%) / 3 TD / 3 INT 139 RUSH YDS / 1 RUSH TD / 46.3 RUSH YPG
Anthony Woods	RB	117 YDS / 0 TD / 39 YPG / 5.6 YPC 10 REC / 91 REC YDS / 1 REC TD / 30.3 REC YPG
Kwazi Gilmer	WR	16 REC / 174 YDS / 0 TD / 58 YPG
Mikey Matthews	WR	10 REC / 123 YDS / 0 TD / 41 YPG
Isaiah Chisom	LB	28 TKL / 1 TFL
JonJon Vaughns	LB	25 TKL / 1 TFL
Key Lawrence	DB	14 TKL / 0 TFL
Kechaun Bennett	DL	7 TKL / 1 TFL / 1 SACK