LSU vs. South Carolina Prediction, Odds, Picks - October 11, 2025

Updated Oct. 11, 2025 3:04 p.m. ET

Data Skrive

The No. 11 LSU Tigers (4-1) are 8.5-point favorites when they host the South Carolina Gamecocks (3-2) in conference action on Saturday, October 11, 2025 at Tiger Stadium. The game's point total is set at 44.5.

The Tigers' last contest was versus the Ole Miss Rebels, and they lost by a score of 24-19. The Gamecocks beat the Kentucky Wildcats, 35-13, in their most recent contest.

Keep up with college football all season on FOX Sports.

LSU vs. South Carolina Game Information & Odds

When: Saturday, October 11, 2025 at 7:45 p.m. ET
Location: Tiger Stadium in Baton Rouge, Louisiana
TV: SEC Network
Live Box Score on FOX Sports

LSU vs South Carolina Betting Information updated as of October 11, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
LSU	-8.5 (-114)	-333	+266	44.5	-110	-110

LSU vs. South Carolina Prediction

Pick ATS: LSU (-8.5)
Pick OU: Under (44.5)
Prediction: LSU 23, South Carolina 14

Predictions are made by the Data Skrive betting model.

Learn more about the LSU Tigers vs. the South Carolina Gamecocks game on FOX Sports!

LSU vs. South Carolina Betting Insights

Based on the spread and over/under, the implied score for the tilt is Tigers 26, Gamecocks 18.
The Tigers have a 76.9% chance to win this game based on the moneyline's implied probability. The Gamecocks hold a 27.3% implied probability.
LSU has covered twice in five matchups with a spread this season.
South Carolina has covered three times in five games with a spread this year.

LSU vs. South Carolina: 2025 Stats Comparison

	LSU	South Carolina
Off. Points per Game (Rank)	27 (92)	24.8 (100)
Def. Points per Game (Rank)	12.2 (6)	18.8 (30)
Turnovers Allowed (Rank)	5 (35)	4 (18)
Turnovers Forced (Rank)	8 (42)	9 (22)

LSU 2025 Key Players

Name	Position	Stats
Garrett Nussmeier	QB	1,157 YDS (67.3%) / 7 TD / 3 INT -17 RUSH YDS / 1 RUSH TD / -3.4 RUSH YPG
Zavion Thomas	WR	14 REC / 178 YDS / 2 TD / 35.6 YPG
Caden Durham	RB	213 YDS / 2 TD / 53.3 YPG / 4.1 YPC
Barion Brown	WR	25 REC / 239 YDS / 1 TD / 47.8 YPG
West Weeks	LB	24 TKL / 1 TFL / 0.5 SACK
Davhon Keys	LB	23 TKL / 0 TFL / 0.5 SACK
Tamarcus Cooley	DB	18 TKL / 0 TFL / 1 INT / 1 PD
PJ Woodland	DB	11 TKL / 1 TFL / 1 SACK / 1 INT

South Carolina 2025 Key Players

Name	Position	Stats
LaNorris Sellers	QB	886 YDS (66.7%) / 4 TD / 1 INT 98 RUSH YDS / 1 RUSH TD / 19.6 RUSH YPG
Vandrevius Jacobs	WR	18 REC / 323 YDS / 2 TD / 80.8 YPG
Rahsul Faison	RB	163 YDS / 3 TD / 32.6 YPG / 4 YPC
Nyck Harbor	WR	11 REC / 220 YDS / 1 TD / 44 YPG
Dylan Stewart	DL	21 TKL / 6 TFL / 4 SACK
Bryan Thomas Jr.	DL	17 TKL / 4 TFL / 3 SACK
Fred Johnson	LB	24 TKL / 1 TFL / 1 SACK / 1 INT
Vicari Swain	DB	14 TKL / 0 TFL