Louisville vs. USC Prediction, Odds, Picks - December 27

Updated Dec. 27, 2023 3:04 p.m. ET

FOX Sports

The Holiday Bowl features a showdown between the Louisville Cardinals (who are 6.5-point favorites) and the USC Trojans on December 27, 2023 at 8:00 PM ET on FOX. The point total is 58.5.

The Cardinals lost versus the Florida State Seminoles in their last game, 16-6. The Trojans lost to the UCLA Bruins, 38-20, in their most recent game.

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Louisville vs. USC Game Information & Odds

When: Wednesday, December 27, 2023 at 8:00 PM ET
Location: Petco Park in Rancho San Diego, California
TV: FOX
Live boxscore on FOX Sports

Louisville vs USC Betting Information updated as of December 27, 2023, 2:45 PM ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Louisville	-6.5 (-111)	-246	+199	58.5	-108	-112

Louisville vs. USC Prediction

Pick ATS: USC (+6.5)
Pick OU: Over (58.5)
Prediction: Louisville 33, USC 31

Learn more about the Louisville Cardinals vs. the USC Trojans game on FOX Sports!

Louisville vs. USC Betting Insights

Based on the spread and over/under, the implied score for the game is Cardinals 32, Trojans 26.
The Cardinals have a 71.1% chance to collect the win in this game based on the moneyline's implied probability. The Trojans have a 33.4% implied probability.
Louisville has won six games against the spread this season, while failing to cover or pushing seven times.
USC has covered three times in 12 chances against the spread this year.

Louisville vs. USC: 2023 Stats Comparison

	Louisville	USC
Off. Points per Game (Rank)	30.9 (41)	41.8 (6)
Def. Points per Game (Rank)	19.7 (29)	34.9 (119)
Turnovers Allowed (Rank)	17 (60)	16 (49)
Turnovers Forced (Rank)	19 (43)	14 (100)

Louisville 2023 Key Players

Name	Position	Stats
Jawhar Jordan	RB	1,128 YDS / 13 TD / 86.8 YPG / 6.2 YPC 21 REC / 246 REC YDS / 1 REC TD / 18.9 REC YPG
Jack Plummer	QB	3,063 YDS (63.5%) / 21 TD / 12 INT 42 RUSH YDS / 1 RUSH TD / 3.2 RUSH YPG
Isaac Guerendo	RB	649 YDS / 8 TD / 49.9 YPG / 6.0 YPC 17 REC / 192 REC YDS / 0 REC TD / 14.8 REC YPG
Jamari Thrash	WR	63 REC / 858 YDS / 6 TD / 66.0 YPG
Ashton Gillotte	DL	34 TKL / 9.0 TFL / 10.0 SACK
Devin Neal	DB	50 TKL / 0.0 TFL / 4 INT / 4 PD
TJ Quinn	LB	72 TKL / 0.0 TFL / 0.5 SACK / 1 INT
Cam'Ron Kelly	DB	49 TKL / 1.0 TFL / 2 INT / 2 PD

USC 2023 Key Players

Name	Position	Stats
Caleb Williams	QB	3,633 YDS (68.4%) / 30 TD / 5 INT 115 RUSH YDS / 11 RUSH TD / 9.6 RUSH YPG
MarShawn Lloyd	RB	820 YDS / 9 TD / 68.3 YPG / 7.1 YPC 13 REC / 232 REC YDS / 0 REC TD / 19.3 REC YPG
Brenden Rice	WR	45 REC / 791 YDS / 12 TD / 65.9 YPG
Tahj Washington	WR	52 REC / 963 YDS / 6 TD / 80.3 YPG
Solomon Byrd	DE	37 TKL / 4.0 TFL / 5.5 SACK
Jamil Muhammad	DE	31 TKL / 7.0 TFL / 6.0 SACK
Mason Cobb	LB	73 TKL / 5.0 TFL
Jaylin Smith	S	56 TKL / 5.0 TFL / 1.0 SACK