Kansas vs. West Virginia Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 3:04 p.m. ET

Data Skrive

The West Virginia Mountaineers (2-1) are 12.5-point underdogs in a road Big 12 matchup with the Kansas Jayhawks (2-1) on Saturday, September 20, 2025 at David Booth Kansas Memorial Stadium. The contest has a point total set at 54.5.

The Jayhawks lost to the Missouri Tigers, 42-31, in their most recent game. The Mountaineers beat the Pittsburgh Panthers, 31-24, in their most recent contest.

Keep up with college football all season on FOX Sports.

Kansas vs. West Virginia Game Information & Odds

When: Saturday, September 20, 2025 at 6 p.m. ET
Location: David Booth Kansas Memorial Stadium in Lawrence, Kansas
TV: Fox Sports 1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Kansas vs West Virginia Betting Information updated as of September 20, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Kansas	-12.5 (-111)	-478	+362	54.5	-108	-115

Kansas vs. West Virginia Prediction

Pick ATS: West Virginia (+12.5)
Pick OU: Under (54.5)
Prediction: Kansas 29, West Virginia 19

Predictions are made by the Data Skrive betting model.

Learn more about the Kansas Jayhawks vs. the West Virginia Mountaineers game on FOX Sports!

Kansas vs. West Virginia Betting Insights

Based on the spread and over/under, the implied score for the tilt is Jayhawks 34, Mountaineers 21.
The Jayhawks have an 82.7% chance to collect the win in this meeting based on the moneyline's implied probability. The Mountaineers hold a 21.6% implied probability.
Kansas has covered once in three matchups with a spread this season.
West Virginia has a record of 2-1-0 against the spread this year.

Kansas vs. West Virginia: Head-to-Head

In their past three head-to-head bouts, West Virginia has won against Kansas two times.
The Jayhawks own a 2-1 record ATS in those games, while the two teams went over the point total each time.
West Virginia has been outpaced by 3 points in its last three tilts versus Kansas.

Kansas vs. West Virginia: 2025 Stats Comparison

	Kansas	West Virginia
Off. Points per Game (Rank)	36 (44)	28.7 (71)
Def. Points per Game (Rank)	18.7 (55)	14.7 (37)
Turnovers Allowed (Rank)	3 (53)	7 (125)
Turnovers Forced (Rank)	4 (47)	6 (14)

Kansas 2025 Key Players

Name	Position	Stats
Jalon Daniels	QB	679 YDS (72%) / 9 TD / 2 INT 82 RUSH YDS / 1 RUSH TD / 27.3 RUSH YPG
Cam Pickett	WR	10 REC / 124 YDS / 3 TD / 41.3 YPG
Emmanuel Henderson Jr.	WR	12 REC / 183 YDS / 2 TD / 61 YPG
DeShawn Hanika	TE	9 REC / 95 YDS / 3 TD / 31.7 YPG
Trey Lathan	LB	23 TKL / 2 TFL / 0.5 SACK
Leroy Harris III	DL	7 TKL / 3 TFL / 3.5 SACK
Bangally Kamara	LB	10 TKL / 3 TFL / 1 SACK
Lyrik Rawls	DB	15 TKL / 1 TFL / 1 INT / 1 PD

West Virginia 2025 Key Players

Name	Position	Stats
Nicco Marchiol	QB	594 YDS (71.8%) / 2 TD / 1 INT 61 RUSH YDS / 1 RUSH TD / 20.3 RUSH YPG
Jahiem White	RB	133 YDS / 3 TD / 66.5 YPG / 5.5 YPC
Tye Edwards	RB	141 YDS / 3 TD / 141 YPG / 5.6 YPC
Cam Vaughn	WR	12 REC / 203 YDS / 1 TD / 67.7 YPG
Chase Wilson	LB	13 TKL / 4 TFL / 3 SACK / 1 INT
Fred Perry	DB	20 TKL / 2 TFL / 2 SACK
Darrian Lewis	DB	22 TKL / 0 TFL / 2 INT / 2 PD
Kekoura Tarnue	DB	17 TKL / 1 TFL