Iowa State vs. Iowa Prediction, Odds, Picks - September 6, 2025

Updated Sep. 6, 2025 9:04 a.m. ET

Data Skrive

The Cy-Hawk Trophy is up for grabs when the No. 16 Iowa State Cyclones (2-0) and the Iowa Hawkeyes (1-0) clash on Saturday, September 6, 2025 at Jack Trice Stadium. The Cyclones are 3.5-point favorites. The over/under is 42.5 in this game.

Facing the South Dakota Coyotes in their most recent contest, the Cyclones won 55-7. Facing the Albany Great Danes in their most recent contest, the Hawkeyes won 34-7.

Keep up with college football all season on FOX Sports.

Will Rocco Becht lead Iowa State to a win over Iowa in the Cy-Hawk rivalry? | Joel Klatt Show

Joel Klatt previewed the Iowa Hawkeyes taking on the Iowa State Cyclones. He analyzed how Iowa State QB Rocco Becht has made great plays in crunch time to help the team win games late. Joel also questioned if the Iowa defense will put pressure on the cyclones, and if the offense led by Mark Gronowski will put up a fight.

Iowa State vs. Iowa Game Information & Odds

When: Saturday, September 6, 2025 at 12 p.m. ET
Location: Jack Trice Stadium in Ames, Iowa
TV: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Iowa State vs Iowa Betting Information updated as of September 6, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Iowa State	-3.5 (-109)	-170	+142	42.5	-111	-109

Iowa State vs. Iowa Prediction

Pick ATS: Iowa State (-3.5)
Pick OU: Over (42.5)
Prediction: Iowa State 28, Iowa 23

Predictions are made by the Data Skrive betting model.

Learn more about the Iowa State Cyclones vs. the Iowa Hawkeyes game on FOX Sports!

Iowa State vs. Iowa Betting Insights

Per the spread and over/under, the implied score for the game is Cyclones 23, Hawkeyes 20.
The Cyclones have a 63.0% chance to win this game per the moneyline's implied probability. The Hawkeyes have a 41.3% implied probability.
Iowa State has covered in each of its two games with a spread this season.
Iowa has compiled a 0-1-0 record against the spread this season.

Iowa State vs. Iowa: Head-to-Head

The last four times Iowa and Iowa State have matched up, the two teams share a split 2-2 record.
The two teams have gone over the total on one occasion while sharing an even 2-2 record in their games against the spread.
Over their last four head-to-head contests, Iowa has racked up 73 points, while Iowa State has tallied 60.

Iowa State vs. Iowa: 2025 Stats Comparison

	Iowa State	Iowa
Off. Points per Game (Rank)	39.5 (2)	34 (55)
Def. Points per Game (Rank)	14 (98)	7 (20)
Turnovers Allowed (Rank)	2 (100)	1 (55)
Turnovers Forced (Rank)	4 (5)	0 (94)

Iowa State 2025 Key Players

Name	Position	Stats
Rocco Becht	QB	461 YDS (68.8%) / 5 TD / 0 INT 33 RUSH YDS / 1 RUSH TD / 16.5 RUSH YPG
Benjamin Brahmer	TE	9 REC / 88 YDS / 2 TD / 44 YPG
Brett Eskildsen	WR	5 REC / 123 YDS / 1 TD / 61.5 YPG
Gabe Burkle	TE	7 REC / 116 YDS / 1 TD / 58 YPG
Jamison Patton	DB	14 TKL / 0 TFL / 1 INT / 1 PD
Kooper Ebel	LB	7 TKL / 1 TFL / 1 SACK
Marcus Neal	DB	12 TKL / 1 TFL
Caleb Bacon	LB	8 TKL / 1 TFL

Iowa 2025 Key Players

Name	Position	Stats
Xavier Williams	RB	122 YDS / 1 TD / 122 YPG / 11.1 YPC
Mark Gronowski	QB	44 YDS (53.3%) / 1 TD / 0 INT 39 RUSH YDS / 1 RUSH TD / 39 RUSH YPG
Terrell Washington Jr.	RB	69 YDS / 0 TD / 69 YPG / 4.6 YPC
Kaden Wetjen	WR	1 REC / 2 YDS / 1 TD / 2 YPG
Aaron Graves	DL	1 TKL / 1 TFL / 1 SACK
Max Llewellyn	DL	1 TKL / 1 TFL / 1 SACK
Jaden Harrell	LB	4 TKL / 0 TFL
Karson Sharar	LB	4 TKL / 0 TFL