Iowa State vs. Arizona Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 3:04 p.m. ET

Data Skrive

Oddsmakers give the No. 14 Iowa State Cyclones (4-0) the edge when they host the Arizona Wildcats (3-0) on Saturday, September 27, 2025 in a matchup between Big 12 opponents at Jack Trice Stadium. Iowa State is favored by 4.5 points. The contest has an over/under of 48.5 points.

In their last action, the Cyclones won versus the Arkansas State Red Wolves, 24-16. The Wildcats' last contest was against the Kansas State Wildcats, and they won by a score of 23-17.

Keep up with college football all season on FOX Sports.

Iowa State vs. Arizona Game Information & Odds

When: Saturday, September 27, 2025 at 7 p.m. ET
Location: Jack Trice Stadium in Ames, Iowa
TV: ESPN
Live Box Score on FOX Sports

Iowa State vs Arizona Betting Information updated as of September 27, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Iowa State	-4.5 (-107)	-185	+154	48.5	-109	-111

Iowa State vs. Arizona Prediction

Pick ATS: Arizona (+4.5)
Pick OU: Under (48.5)
Prediction: Arizona 21, Iowa State 20

Predictions are made by the Data Skrive betting model.

Learn more about the Iowa State Cyclones vs. the Arizona Wildcats game on FOX Sports!

Iowa State vs. Arizona Betting Insights

Per the spread and over/under, the implied score for the matchup is Cyclones 26, Wildcats 22.
The Cyclones have a 64.9% chance to claim victory in this game per the moneyline's implied probability. The Wildcats hold a 39.4% implied probability.
Iowa State has covered twice in four games with a spread this season.
Arizona has put together a perfect 2-0-0 record against the spread this season.

Iowa State vs. Arizona: 2025 Stats Comparison

	Iowa State	Arizona
Off. Points per Game (Rank)	29.8 (63)	37 (72)
Def. Points per Game (Rank)	14.3 (28)	8.7 (4)
Turnovers Allowed (Rank)	4 (50)	2 (17)
Turnovers Forced (Rank)	6 (27)	8 (9)

Iowa State 2025 Key Players

Name	Position	Stats
Rocco Becht	QB	860 YDS (65%) / 7 TD / 1 INT 48 RUSH YDS / 2 RUSH TD / 12 RUSH YPG
Carson Hansen	RB	252 YDS / 0 TD / 63 YPG / 4.7 YPC 7 REC / 46 REC YDS / 0 REC TD / 11.5 REC YPG
Abu Sama III	RB	182 YDS / 2 TD / 45.5 YPG / 4.8 YPC
Benjamin Brahmer	TE	14 REC / 109 YDS / 3 TD / 27.3 YPG
Marcus Neal	DB	28 TKL / 4 TFL / 1 SACK
Jamison Patton	DB	22 TKL / 0 TFL / 1 INT / 1 PD
Kooper Ebel	LB	17 TKL / 1 TFL / 1 SACK
Tamatoa McDonough	DL	9 TKL / 2 TFL / 2 SACK

Arizona 2025 Key Players

Name	Position	Stats
Noah Fifita	QB	712 YDS (59%) / 6 TD / 0 INT 37 RUSH YDS / 3 RUSH TD / 12.3 RUSH YPG
Ismail Mahdi	RB	263 YDS / 1 TD / 87.7 YPG / 7.1 YPC 4 REC / 56 REC YDS / 1 REC TD / 18.7 REC YPG
Jayin Whatley	WR	13 REC / 237 YDS / 2 TD / 79 YPG
Quincy Craig	RB	165 YDS / 1 TD / 55 YPG / 9.2 YPC
Chase Kennedy	LB	5 TKL / 2 TFL / 2 SACK
Genesis Smith	DB	12 TKL / 0 TFL / 1 INT / 4 PD
Jay'Vion Cole	DB	6 TKL / 1 TFL / 1 SACK / 1 INT
Dalton Johnson	DB	13 TKL / 0 TFL