Illinois vs. Northwestern Prediction, Odds, Picks - November 29, 2025

Updated Nov. 29, 2025 3:04 p.m. ET

Data Skrive

The Illinois Fighting Illini (7-4) and the Northwestern Wildcats (6-5) take the field with the Land of Lincoln Trophy up for grabs on Saturday, November 29, 2025 at Memorial Stadium (Champaign, IL). The Fighting Illini are favored by 7 points in the game. This game has an over/under of 45.5 points.

Against the Wisconsin Badgers in their last contest, the Fighting Illini lost 27-10. In their last contest, the Wildcats won against the Minnesota Golden Gophers, 38-35.

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Illinois vs. Northwestern Game Information & Odds

When: Saturday, November 29, 2025 at 7:30 p.m. ET
Location: Memorial Stadium (Champaign, IL) in Champaign, Illinois
TV: FOX
Streaming: FOX One (Limited time offer: 50% off the first two months)

Illinois vs Northwestern Betting Information updated as of November 29, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Illinois	-7 (-111)	-275	+225	45.5	-112	-108

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Illinois vs. Northwestern Prediction

Pick ATS: Illinois (-7)
Pick OU: Over (45.5)
Prediction: Illinois 31, Northwestern 18

Predictions are made by the Data Skrive betting model.

Learn more about the Illinois Fighting Illini vs. the Northwestern Wildcats game on FOX Sports!

Illinois vs. Northwestern Betting Insights

Per the spread and over/under, the implied score for the tilt is Fighting Illini 26, Wildcats 19.
The Fighting Illini have a 73.3% chance to claim victory in this meeting based on the moneyline's implied probability. The Wildcats have a 30.8% implied probability.
Illinois is 7-4-0 ATS this season.
Northwestern has put together a 6-4-1 record against the spread this year.

Illinois vs. Northwestern: Head-to-Head

Over their last four meetings, Illinois has tallied three wins against Northwestern.
The Fighting Illini own a 3-1 record ATS in those games, while the two teams went over the total each time.
In their last four head-to-head matchups, Illinois has tallied 169 points versus Northwestern, while surrendering only 90 points.

Illinois vs. Northwestern: 2025 Stats Comparison

	Illinois	Northwestern
Off. Points per Game (Rank)	30.2 (55)	23.4 (102)
Def. Points per Game (Rank)	24.2 (55)	21 (33)
Turnovers Allowed (Rank)	10 (11)	16 (87)
Turnovers Forced (Rank)	11 (101)	15 (54)

Illinois 2025 Key Players

Name	Position	Stats
Luke Altmyer	QB	2,675 YDS (68.1%) / 21 TD / 5 INT 190 RUSH YDS / 4 RUSH TD / 17.3 RUSH YPG
Hank Beatty	WR	61 REC / 805 YDS / 3 TD / 73.2 YPG
Kaden Feagin	RB	486 YDS / 6 TD / 44.2 YPG / 4.3 YPC 15 REC / 172 REC YDS / 2 REC TD / 21.5 REC YPG
Collin Dixon	WR	31 REC / 485 YDS / 5 TD / 44.1 YPG
Gabe Jacas	LB	36 TKL / 4 TFL / 9 SACK
Matthew Bailey	DB	64 TKL / 2 TFL
Miles Scott	DB	40 TKL / 3 TFL / 1 SACK / 1 INT
Dylan Rosiek	LB	35 TKL / 2 TFL / 1 INT / 1 PD

Northwestern 2025 Key Players

Name	Position	Stats
Caleb Komolafe	RB	886 YDS / 10 TD / 80.5 YPG / 5.1 YPC 9 REC / 51 REC YDS / 1 REC TD / 6.4 REC YPG
Preston Stone	QB	2,011 YDS (60.7%) / 13 TD / 9 INT 22 RUSH YDS / 1 RUSH TD / 2 RUSH YPG
Griffin Wilde	WR	56 REC / 755 YDS / 6 TD / 68.6 YPG
Joseph Himon II	RB	475 YDS / 1 TD / 47.5 YPG / 4.9 YPC 21 REC / 118 REC YDS / 0 REC TD / 11.8 REC YPG
Mac Uihlein	LB	76 TKL / 4 TFL / 4 INT / 4 PD
Robert Fitzgerald	DB	87 TKL / 5 TFL / 1 INT / 1 PD
Braydon Brus	LB	55 TKL / 2 TFL / 1.5 SACK
Braden Turner	DB	39 TKL / 1 TFL / 1 INT / 1 PD