College Football Upsets from Week 4

Who doesn't like upsets? We certainly had some in college football in Week 4 of the 2025 campaign. Scroll down for all the details.

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Biggest College Football Upsets This Week

Syracuse 34, Clemson 21

• Home Team: Clemson
• Spread Favorite: Clemson (-17.5)
• Moneyline: Clemson -800, Syracuse +550
• O/U: Over (54.5)
• Box Score

Coastal Carolina 38, South Alabama 20

• Home Team: South Alabama
• Spread Favorite: South Alabama (-15.5)
• Moneyline: South Alabama -676, Coastal Carolina +490
• O/U: Over (51.5)
• Box Score

San Diego State 34, California 0

• Home Team: San Diego State
• Spread Favorite: California (-14)
• Moneyline: California -575, San Diego State +425
• O/U: Under (47.5)
• Box Score

Western Michigan 14, Toledo 13

• Home Team: Western Michigan
• Spread Favorite: Toledo (-13.5)
• Moneyline: Toledo -521, Western Michigan +390
• O/U: Under (49.5)
• Box Score

Maryland 27, Wisconsin 10

• Home Team: Wisconsin
• Spread Favorite: Wisconsin (-10)
• Moneyline: Wisconsin -410, Maryland +320
• O/U: Under (44.5)
• Box Score

Tulsa 19, Oklahoma State 12

• Home Team: Oklahoma State
• Spread Favorite: Oklahoma State (-10)
• Moneyline: Oklahoma State -360, Tulsa +285
• O/U: Under (54.5)
• Box Score

Memphis 32, Arkansas 31

• Home Team: Memphis
• Spread Favorite: Arkansas (-7.5)
• Moneyline: Arkansas -270, Memphis +220
• O/U: Over (60.5)
• Box Score

San Diego 42, Princeton 35

• Home Team: Princeton
• Spread Favorite: Princeton (-7.5)
• Moneyline: Princeton -298, San Diego +240
• O/U: Over (49.5)
• Box Score

Utah Tech 20, Northern Iowa 9

• Home Team: Utah Tech
• Spread Favorite: Northern Iowa (-6.5)
• Moneyline: Northern Iowa -205, Utah Tech +170
• O/U: Under (50.5)
• Box Score

Louisiana-Monroe 31, UTEP 25

• Home Team: UTEP
• Spread Favorite: UTEP (-5.5)
• Moneyline: UTEP -218, Louisiana-Monroe +180
• O/U: Over (47.5)
• Box Score

Troy 21, Buffalo 17

• Home Team: Buffalo
• Spread Favorite: Buffalo (-5.5)
• Moneyline: Buffalo -225, Troy +185
• O/U: Under (44.5)
• Box Score

Kennesaw State 28, Arkansas State 21

• Home Team: Kennesaw State
• Spread Favorite: Arkansas State (-4.5)
• Moneyline: Arkansas State -192, Kennesaw State +160
• O/U: Under (58.5)
• Box Score

Delaware 38, Florida International 16

• Home Team: Florida International
• Spread Favorite: Florida International (-4)
• Moneyline: Florida International -180, Delaware +150
• O/U: Under (54.5)
• Box Score

Howard 34, Hampton 7

• Home Team: Howard
• Spread Favorite: Hampton (-3.5)
• Moneyline: Hampton -185, Howard +154
• O/U: Under (46.5)
• Box Score

Texas Tech 34, Utah 10

• Home Team: Utah
• Spread Favorite: Utah (-3.5)
• Moneyline: Utah -175, Texas Tech +145
• O/U: Under (58.5)
• Box Score

Lindenwood 30, Stony Brook 27

• Home Team: Lindenwood
• Spread Favorite: Stony Brook (-3.5)
• Moneyline: Stony Brook -170, Lindenwood +142
• O/U: Under (57.5)
• Box Score

Albany 13, Cornell 10

• Home Team: Albany
• Spread Favorite: Cornell (-3)
• Moneyline: Cornell -162, Albany +136
• O/U: Under (50.5)
• Box Score

Dartmouth 27, New Hampshire 20

• Home Team: Dartmouth
• Spread Favorite: New Hampshire (-2.5)
• Moneyline: New Hampshire -142, Dartmouth +120
• O/U: Over (46.5)
• Box Score

Abilene Christian 45, Austin Peay 31

• Home Team: Abilene Christian
• Spread Favorite: Austin Peay (-2.5)
• Moneyline: Austin Peay -130, Abilene Christian +110
• O/U: Over (54.5)
• Box Score

Dayton 17, Robert Morris 14

• Home Team: Robert Morris
• Spread Favorite: Robert Morris (-2.5)
• Moneyline: Robert Morris -130, Dayton +110
• O/U: Under (42.5)
• Box Score

Eastern Michigan 34, Louisiana 31

• Home Team: Eastern Michigan
• Spread Favorite: Louisiana (-2.5)
• Moneyline: Louisiana -135, Eastern Michigan +114
• O/U: Over (51.5)
• Box Score

Brown 46, Georgetown 0

• Home Team: Brown
• Spread Favorite: Georgetown (-2.5)
• Moneyline: Georgetown -170, Brown +142
• O/U: Under (58.5)
• Box Score

Arizona State 27, Baylor 24

• Home Team: Baylor
• Spread Favorite: Baylor (-2.5)
• Moneyline: Baylor -135, Arizona State +114
• O/U: Under (60.5)
• Box Score

Sacred Heart 31, Norfolk State 28

• Home Team: Norfolk State
• Spread Favorite: Norfolk State (-1.5)
• Moneyline: Norfolk State -118, Sacred Heart -102
• O/U: Over (47.5)
• Box Score

Campbell 50, Bryant 48

• Home Team: Campbell
• Spread Favorite: Bryant (-1.5)
• Moneyline: Bryant -120, Campbell +100
• O/U: Over (51.5)
• Box Score

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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