College Football Top 25 Week 12 2025 Predictions, Betting Odds & TV Schedule

There are 20 games on the college football schedule in Week 12 that feature a ranked team. That includes the No. 10 Texas Longhorns versus the No. 5 Georgia Bulldogs.

Searching for an edge in college football? We break down the betting odds for each of the big matchups below.

Check out the full college football schedule on FOX Sports! Or visit FOX Sports' college football hub for everything you need to make the most of this season’s action.

Week 12 Betting Lines & Game Info

No. 19 Louisville Cardinals vs. Clemson Tigers

Odds & Prediction

• Spread: Cardinals (-2.5)
• Moneyline: Cardinals -125, Tigers +105
• Total: 51.5 points
• Prediction: Louisville 31, Clemson 20

How to Watch

• Game Date: Friday, Nov. 14
• Game Time: 7:30 p.m. ET
• TV Channel: ESPN
• Location: Louisville, Kentucky
• Box Score

No. 7 Oregon Ducks vs. Minnesota Golden Gophers

Odds & Prediction

• Spread: Ducks (-26.5)
• Moneyline: Ducks -3571, Golden Gophers +1500
• Total: 45.5 points
• Prediction: Oregon 35, Minnesota 11

How to Watch

• Game Date: Friday, Nov. 14
• Game Time: 9 p.m. ET
• TV Channel: FOX
• Location: Eugene, Oregon
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

No. 3 Texas A&M Aggies vs. South Carolina Gamecocks

Odds & Prediction

• Spread: Aggies (-16.5)
• Moneyline: Aggies -901, Gamecocks +600
• Total: 50.5 points
• Prediction: Texas A&M 38, South Carolina 13

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 12 p.m. ET
• TV Channel: ESPN
• Location: College Station, Texas
• Box Score

Northwestern Wildcats vs. No. 18 Michigan Wolverines

Odds & Prediction

• Spread: Wolverines (-10.5)
• Moneyline: Wolverines -410, Wildcats +320
• Total: 42.5 points
• Prediction: Michigan 25, Northwestern 17

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 12 p.m. ET
• TV Channel: FOX
• Location: Chicago, Illinois
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

No. 23 Pittsburgh Panthers vs. No. 9 Notre Dame Fighting Irish

Odds & Prediction

• Spread: Fighting Irish (-13.5)
• Moneyline: Fighting Irish -455, Panthers +350
• Total: 54.5 points
• Prediction: Notre Dame 32, Pittsburgh 26

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 12 p.m. ET
• TV Channel: ABC
• Location: Pittsburgh, Pennsylvania
• Box Score

No. 22 Cincinnati Bearcats vs. Arizona Wildcats

Odds & Prediction

• Spread: Bearcats (-5.5)
• Moneyline: Bearcats -218, Wildcats +180
• Total: 56.5 points
• Prediction: Cincinnati 28, Arizona 27

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 12 p.m. ET
• TV Channel: FS1
• Location: Cincinnati, Ohio
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

No. 2 Indiana Hoosiers vs. Wisconsin Badgers

Odds & Prediction

• Spread: Hoosiers (-29.5)
• Moneyline: Hoosiers -4545, Badgers +1700
• Total: 44.5 points
• Prediction: Indiana 40, Wisconsin 5

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 12 p.m. ET
• TV Channel: BTN
• Location: Bloomington, Indiana
• Box Score

Duke Blue Devils vs. No. 20 Virginia Cavaliers

Odds & Prediction

• Spread: Blue Devils (-4.5)
• Moneyline: Blue Devils -192, Cavaliers +160
• Total: 60.5 points
• Prediction: Duke 31, Virginia 28

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 3:30 p.m. ET
• TV Channel: ESPN2
• Location: Wilmington, North Carolina
• Box Score

Boston College Eagles vs. No. 14 Georgia Tech Yellow Jackets

Odds & Prediction

• Spread: Yellow Jackets (-16.5)
• Moneyline: Yellow Jackets -847, Eagles +575
• Total: 61.5 points
• Prediction: Georgia Tech 39, Boston College 18

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 3:30 p.m. ET
• TV Channel: ACC Network
• Location: Boston, Massachusetts
• Box Score

No. 24 James Madison Dukes vs. Appalachian State Mountaineers

Odds & Prediction

• Spread: Dukes (-21.5)
• Moneyline: Dukes -1786, Mountaineers +1000
• Total: 53.5 points
• Prediction: James Madison 39, Appalachian State 15

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 3:30 p.m. ET
• TV Channel: ESPN+
• Location: Harrisonburg, Virginia
• Box Score

No. 16 Miami (FL) Hurricanes vs. North Carolina State Wolfpack

Odds & Prediction

• Spread: Hurricanes (-14.5)
• Moneyline: Hurricanes -649, Wolfpack +470
• Total: 54.5 points
• Prediction: Miami (FL) 37, NC State 18

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 3:30 p.m. ET
• TV Channel: ESPN
• Location: Miami Gardens, Florida
• Box Score

No. 8 Texas Tech Red Raiders vs. UCF Knights

Odds & Prediction

• Spread: Red Raiders (-24.5)
• Moneyline: Red Raiders -2778, Knights +1300
• Total: 48.5 points
• Prediction: Texas Tech 39, UCF 9

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 3:30 p.m. ET
• TV Channel: FOX
• Location: Lubbock, Texas
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

No. 17 USC Trojans vs. Iowa Hawkeyes

Odds & Prediction

• Spread: Trojans (-7)
• Moneyline: Trojans -230, Hawkeyes +190
• Total: 48.5 points
• Prediction: USC 30, Iowa 22

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 3:30 p.m. ET
• TV Channel: BTN
• Location: Los Angeles, California
• Box Score

No. 4 Alabama Crimson Tide vs. No. 11 Oklahoma Sooners

Odds & Prediction

• Spread: Crimson Tide (-6.5)
• Moneyline: Crimson Tide -250, Sooners +205
• Total: 46.5 points
• Prediction: Alabama 26, Oklahoma 20

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 3:30 p.m. ET
• TV Channel: ABC
• Location: Tuscaloosa, Alabama
• Box Score

No. 21 Tennessee Volunteers vs. New Mexico State Aggies

Odds & Prediction

• Spread: Volunteers (-41.5)
• Moneyline: Volunteers , Aggies
• Total: 60.5 points
• Prediction: Tennessee 46, New Mexico State 15

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 4:15 p.m. ET
• TV Channel: SEC Network
• Location: Knoxville, Tennessee
• Box Score

No. 6 Ole Miss Rebels vs. Florida Gators

Odds & Prediction

• Spread: Rebels (-10.5)
• Moneyline: Rebels -441, Gators +340
• Total: 53.5 points
• Prediction: Ole Miss 32, Florida 17

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 7 p.m. ET
• TV Channel: ESPN
• Location: Oxford, Mississippi
• Box Score

Baylor Bears vs. No. 15 Utah Utes

Odds & Prediction

• Spread: Utes (-9.5)
• Moneyline: Utes -360, Bears +285
• Total: 60.5 points
• Prediction: Utah 37, Baylor 21

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 7 p.m. ET
• TV Channel: ESPN2
• Location: Waco, Texas
• Box Score

No. 1 Ohio State Buckeyes vs. UCLA Bruins

Odds & Prediction

• Spread: Buckeyes (-34.5)
• Moneyline: Buckeyes -9091, Bruins +2500
• Total: 46.5 points
• Prediction: Ohio State 40, UCLA 6

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 7:30 p.m. ET
• TV Channel: NBC
• Location: Columbus, Ohio
• Box Score

No. 5 Georgia Bulldogs vs. No. 10 Texas Longhorns

Odds & Prediction

• Spread: Bulldogs (-4.5)
• Moneyline: Bulldogs -192, Longhorns +160
• Total: 49.5 points
• Prediction: Georgia 31, Texas 20

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 7:30 p.m. ET
• TV Channel: ABC
• Location: Athens, Georgia
• Box Score

No. 12 BYU Cougars vs. TCU Horned Frogs

Odds & Prediction

• Spread: Cougars (-3)
• Moneyline: Cougars -155, Horned Frogs +130
• Total: 51.5 points
• Prediction: BYU 33, TCU 20

How to Watch

• Game Date: Saturday, Nov. 15
• Game Time: 10:15 p.m. ET
• TV Channel: ESPN
• Location: Provo, Utah
• Box Score

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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